20.500.12556/DiRROS-29034 Influenza C virus in children with acute bronchiolitis and febrile seizures Background: Influenza C virus (ICV), a lesser-known member of the Orthomyxoviridae family, usually causes mild respiratory illness in children. Due to its low prevalence and clinical similarity to other respiratory infections, it is not routinely screened. This study investigates the detection of ICV in children with acute bronchiolitis (AB) and febrile seizures (FS), comparing the findings with a healthy control group. Methods: Between October 2009 and September 2011, 499 nasopharyngeal swabs were collected from children up to 6 years old at the University Medical Center Ljubljana. The study group included 307 children diagnosed with AB and 192 with FS, and 150 healthy control children. Respiratory viruses, including ICV, were detected using real-time polymerase chain reaction. ICV-positive samples were further analyzed by Sanger sequencing and phylogenetic analysis. Results: ICV was detected in 1.3% (4/307) of children with AB and 2.6% (5/192) of those with FS, but in none of the healthy controls. Coinfections occurred in 56% (5/9 cases) of ICV-positive children. ICV was the only virus identified in 1 AB and 3 FS cases. Among AB children, ICV positivity was associated with a more severe disease, including 1 child requiring 5 days of oxygen therapy. Phylogenetic analysis demonstrated that all Slovenian ICV strains belonged to clade I, closely related to the Yamagata lineage. Conclusions: ICV was detected at low frequencies but exclusively in hospitalized children with AB and FS, not in healthy controls. These findings suggest a possible role of ICV in pediatric respiratory illnesses and seizure-associated infections. acute bronchiolitis clinical study fabrile seizures influenza C virus pediatric patients akutni bronhiolitis klinična študija febrilni napadi virus influence C pediatrični bolniki true false true Angleški jezik Slovenski jezik Neznano 2026-04-17 14:44:29 2026-04-17 14:44:30 2026-04-18 03:52:06 0000-00-00 00:00:00 2026 0 0 str. 432-436 iss. [5 Vol. 45 May 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 0891-3668 10.1097/INF.0000000000005089 263949059 RAZ_Jevsnik_Virant_Monika_2026.pdf RAZ_Jevsnik_Virant_Monika_2026.pdf 1 BDF9ACDF3CBCF9349E47F83EA319EA2F 80859b55fca03c778ac5179117d4a0df3933b0cfa86a2c234f10fa41571c372f 45f787f0-3a5b-11f1-a7d2-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43349 https://journals.lww.com/pidj/fulltext/9900/influenza_c_virus_in_children_with_acute.1562.aspx 1 2e56f1ba-3a5b-11f1-a7d2-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43348 Univerzitetni klinični center Ljubljana 0 0 0