20.500.12556/DiRROS-29031 Acute human bocavirus 1 infection in children hospitalized for acute bronchiolitis a 2-year prospective study Background: The objective of this prospective study was to assess the proportion and clinical consequences of human bocavirus 1 (HBoV1) replication in children hospitalized for acute bronchiolitis (AB) with HBoV1 DNA in the nasopharynx (NP). Methods: We studied the clinical presentation of acute HBoV1 infection (with detected mRNA in respiratory samples) among infected children and compared it to the clinical presentation in children with only HBoV1 DNA detected in samples (no viable HBoV1) and other children negative for HBoV1 DNA. Results: HBoV1 DNA was detected in the nasopharynx (NP) of 37/307 patients with AB (12.1%) and in 9/150 children in a healthy control group (6%) with a high co-detection rate with other respiratory viruses in AB patients, 28/37 (75.7%). Only nine out of 37 HBoV1 DNA‒positive NP swabs (24.3%) were also HBoV1 mRNA positive; in all of them, HBoV1 DNA was also detected in plasma. Conclusions: Based on the results of our study, we can conclude that in children with AB acute HBoV1 infection has a high HBoV1 DNA load in NP samples together with detected HBoV1 mRNA and detected HBoV1 DNA in plasma. HBoV1 HBoV1 mRNA acute bronchiolitis virus replication respiratory samples HBoV1 HBoV1 mRNA akutni bronhiolitis razmnoževanje virusa respiratorni vzorci true false true Angleški jezik Slovenski jezik Neznano 2026-04-17 14:32:05 2026-04-17 14:32:05 2026-04-18 03:52:05 0000-00-00 00:00:00 2025 0 0 str. 195-199 iss. 3 Vol. 44 Mar. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 0891-3668 10.1097/INF.0000000000004613 213600515 RAZ_Ursic_Tina_2025.pdf RAZ_Ursic_Tina_2025.pdf 1 70E85EB0C845701566502FFBF49A3D26 991ac8a790df3b23c2875642cefb08621781fc31ea7151743e465be971792ce6 8de3f260-3a59-11f1-a7d2-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43345 https://journals.lww.com/pidj/fulltext/9900/acute_human_bocavirus_1_infection_in_children.1110.aspx 1 74531441-3a59-11f1-a7d2-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43344 Univerzitetni klinični center Ljubljana 0 0 0