20.500.12556/DiRROS-29001 Association of trace elements with polycystic ovary syndrome in women - a case-control study Association of trace elements with polycystic ovary syndrome in women—a case-control study Objectives: There are still limited or lacking data on the association of trace elements (TEs) with polycystic ovary syndrome (PCOS). This case–control study aimed to determine levels of essential TEs (manganese (Mn), copper (Cu), zinc (Zn), selenium (Se), molybdenum (Mo)) and non-essential TEs (arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb)) in urine, whole blood, and serum to investigate a possible association with kidney and liver function, endocrine and metabolic parameters, and environmental and lifestyle sources of potential exposure and provide possible recommendations. Methods: In our case–control study, women with PCOS (n = 35) and healthy controls (n = 35) underwent clinical and ultrasonographic examination, filled in questionnaires targeting general, lifestyle, and environmental information, and provided fasting venous blood samples and first morning urine for biochemical, hormonal, and TE analysis. Multiple linear regression models were used to evaluate the association between TE levels and data obtained through questionnaires. Results: In women with PCOS, lower Mo levels in whole blood (p = 0.024) and serum (p = 0.011) and higher serum Cu levels (p = 0.026) were detected when compared to healthy controls. Results of this study show that amendments in Cu and Mo levels might be related to altered kidney and liver function and disrupted hormonal balance in PCOS women. Cu levels positively correlated with leukocyte count. There was a negative correlation of Mo levels with proteinuria and luteinizing hormone levels. Regarding liver function, Mo negatively correlated with urinary bilirubin levels, and there was a positive association with alanine and aspartate aminotransferase, respectively. Dietary supplement consumption and certain diet habits appeared to be important predictors of exposure to Cu (beef consumption) or Mo (cereal and boiled vegetable consumption) and modify Mo and Cu levels in women. Conclusions: Concentrations of the chemical elements Mo and Cu in biological samples of women appear to be related to PCOS and nutrition. To our knowledge, this is a novel finding for Mo. Additional research is needed to provide more insights into the causality of the PCOS relationship with Mo and Cu in humans. essential elements non-essential elements polycystic ovary syndrome endocrine disruptors hepatic damage trace elements esencialni elementi neesencialni elementi sindrom policističnih jajčnikov prehrambene navade endokrini motilci poškodbe jeter elementi v sledovih true false true Angleški jezik Slovenski jezik Slovenija; Neznano 2026-04-16 10:45:03 2026-04-16 10:45:03 2026-04-17 03:55:04 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 30. 1. 2025; str. 1-25 iss. 2, [article no.] 79 Vol. 15 Feb. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.1 2218-1989 10.3390/metabo15020079 224533507 RAZ_Srnovrsnik_Tinkara_2025.pdf RAZ_Srnovrsnik_Tinkara_2025.pdf 1 E667A14F984BA20D814B42E16265213B 7b39ca19cefd0fbe3afd4c99646f1131075d46255217196b6725c83d972f903c b710e3b7-3970-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43290 https://www.mdpi.com/2218-1989/15/2/79 1 915395eb-3970-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43289 Univerzitetni klinični center Ljubljana 0 0 0