20.500.12556/DiRROS-28998 Effect of led photobiomodulation on tooth movement, gingival hypertrophy and pain in response to treatment with fixed orthodontic appliance Photobiomodulation (PBM) is a form of treatment that uses low-power red and near-infrared light to stimulate tissue repair and regeneration at the cellular level. 32 subjects (198 teeth examined), 10 males and 22 females aged 14.6 ± 2.0 years, with mild dental crowding were included in a randomised, controlled clinical trial. The patients were treated with a fixed orthodontic appliance (FOA). Subjects were randomised into an experimental group (a PBM group irradiated with an LED light source with wavelengths of 625 nm, 660 nm and 850 nm simultaneously and an irradiance of 16 mW/cm²) and a placebo control group that received non-therapeutic irradiation with visible light. PBM therapy began within the first 2 days of appliance insertion and was administered twice weekly for 4 weeks. The rate of tooth movement (a change in distance at the same selected point on the occlusal plane of the tooth determined by measurements on 3D models), the presence of gingival hypertrophy (with a free gingival margin of at least 1 mm occlusal to the enamel-cement junction), the plaque index (PI), the sulcus bleeding index (SBI) and the subjective pain sensation using the visual analogue scale (VAS) were monitored. In the experimental PBM group (N = 14), the rate of movement with the FOA was statistically significantly higher at both 1 week of placement (0.5 mm [95%CI: 0.4-0.8]) and 4 weeks (1.1 mm [95%CI: 0.8-1.4]) than in the placebo group (N = 18), where the values were (0.4 mm [95%CI: 0.2-0.5]) at 1 week and (0.6 mm [95%CI: 0.4-0.9]) at 4 weeks. A lower incidence of gingival hypertrophy was observed in the PBM group (21.4%) than in the placebo group (55.6%) after 4 weeks (Mann-Whitney U-test, p < 0.05). PBM with LED accelerated orthodontic tooth movement during the levelling and alignment phase and reduced the incidence of gingival hypertrophy. orthodontic tooth movement pain photobiomodulation ortodontski premik zoba bolečina fotobiomodulacija true false true Angleški jezik Slovenski jezik Neznano 2026-04-16 09:15:38 2026-04-16 09:15:39 2026-04-17 03:55:04 0000-00-00 00:00:00 2025 0 0 str. 200-1-200-14 no. 1 Vol. 40 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.31 0268-8921 10.1007/s10103-025-04444-5 234362115 RAZ_Sedej_Anja_2025.pdf RAZ_Sedej_Anja_2025.pdf 1 940FC0B198E7F6E0117631F1EBEF2ED5 0349367e778cbb81d31e6cc7280e37fbbea2ef80f587635ddd58e0aaac7a82ba 2e048314-3964-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43284 Univerzitetni klinični center Ljubljana 0 0 0