20.500.12556/DiRROS-28993 Supplemental iron and recombinant erythropoietin for anemia in infants born very preterm a survey of clinical practice in Europe Objectives: To survey practices of iron and recombinant human erythropoietin (rhEpo) administration to infants born preterm across Europe. Study design: Over a 3-month period, we conducted an online survey in 597 neonatal intensive care units (NICUs) of 18 European countries treating infants born with a gestational age of <32 weeks. Results: We included 343 NICUs (response rate 56.3%) in the survey. Almost all NICUs (97.7%) routinely supplement enteral iron, and 74.3% of respondents to all infants born <32 weeks of gestation. We found that 65.3% of NICUs routinely evaluate erythropoiesis and iron parameters beyond day 28 after birth. Most NICUs initiate iron supplementation at postnatal age of 2 weeks and stop after 6 months (34.3%) or 12 months (34.3%). Routine use of rhEpo was reported in 22.2% of NICUs, and in individual cases in 6.9%. RhEpo was mostly administered subcutaneously (70.1%) and most frequently at a dose of 250 U/kg 3 times a week (44.3%), but the dose varied greatly between centers. Conclusions: This survey highlights wide heterogeneity in evaluating erythropoietic activity and iron deficiency in infants born preterm. Variation in iron supplementation during infancy likely reflects an inadequate evidence base. Current evidence on the efficacy and safety profile of rhEpo is only poorly translated into clinical practice. This survey demonstrates a need for standards to optimize patient blood management in anemia of prematurity neonate prematurity recombinant human erythropoietin very low birth weight infant true false true Angleški jezik Ni določen Neznano 2026-04-15 15:04:26 2026-04-15 15:04:27 2026-04-16 04:06:23 0000-00-00 00:00:00 2025 0 0 str. 1-8 Vol. 276 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-053.2 0022-3476 10.1016/j.jpeds.2024.114302 213510915 RAZ_Reibel-Georgi_Nora_J._2025.pdf RAZ_Reibel-Georgi_Nora_J._2025.pdf 1 C418CC17A5D2078E35E0F2247CBB8000 f3267428decba58226acd48a9064a3e692092d4ab2388ea66906e40539f2a7d8 cff8a83c-38cb-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43275 Univerzitetni klinični center Ljubljana 0 0 0