20.500.12556/DiRROS-28984 Assessing health-related quality of life outcomes through sensory modulation profiles in adults with atypical sensory processing: a cross-sectional study Introduction: Atypical sensory modulation—manifesting as low registration, sensitivity, avoidance, or sensory seeking—can significantly affect adults’ daily functioning and health-related quality of life (HRQoL). Despite growing interest in sensory diversity, its relationship with HRQoL remains insufficiently explored in adult populations. Objectives: This study investigated the association between sensory modulation profiles and HRQoL outcomes in adults, with the aim of informing neurodiversity-affirming clinical approaches. Methods: A cross-sectional study included 86 adults (aged 23–54), evenly divided into two groups based on typical vs. atypical sensory modulation profiles, assessed via the Adolescent/Adult Sensory Profile (AASP). HRQoL was measured using the SF-36. Statistical analyses included the Kolmogorov–Smirnov test, Mann–Whitney U test, and Pearson’s correlation. Results: Adults with atypical sensory modulation profiles reported significantly lower HRQoL across all eight SF-36 domains (p < .001), most notably in domains related to fatigue, pain, mental health, and social functioning. No significant associations were found between HRQoL outcomes and age or gender, suggesting sensory modulation profiles were the primary factor. Conclusion: Sensory modulation differences are strongly associated with reduced HRQoL, independent of demographic factors. These findings underscore the importance of integrating sensory-informed, person-centered strategies in adult care to support well-being and promote environmental accommodation over pathologisation. sensory modulation disorder sensory integration dysfunction sensory processing disorder health-related quality of life health status indicators adults sf-36 questionnaire cross-sectional study motnja senzorične modulacije disfunkcija senzorične integracije motnja senzorične obdelave kakovost življenja povezana z zdravjem kazalniki zdravstvenega stanja odrasli vprašalnik SF-36 presečna študija true false true Angleški jezik Slovenski jezik Neznano 2026-04-15 14:01:36 2026-04-15 14:01:36 2026-04-16 04:06:22 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 24. 10. 2025; 7 str. no. 1 Vol. 4 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8-009-053.8 2820-5480 10.33700/jhrs.4.1.153 254722819 RAZ_Goubar_Patricija_2025.pdf RAZ_Goubar_Patricija_2025.pdf 1 48DB17842C098415C3EC2BFF2FC0ACA2 5ac484facb2ed304bf093a47b41e9e89bc574c6a44d544f700f1255a5443799e 08f1c6eb-38c3-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43260 https://jhrs.almamater.si/jhrs/article/view/153 1 dbb83b05-38c2-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43259 Univerzitetni klinični center Ljubljana 0 0 0