20.500.12556/DiRROS-28956 Growth arrest-specific protein 6 is elevated in endometriosis but shows poor diagnostic performance Growth arrest-specific protein 6 (GAS6) has an important role in regulating the immune system. Recent studies have revealed its association with the pathophysiology of endometriosis and identified GAS6 as one of the hub genes and a biomarker candidate. Endometriosis is a common chronic inflammatory gynaecological disease of women of childbearing age. Due to surgical diagnosis, non-invasive biomarkers are urgently needed. We investigated GAS6 as a candidate biomarker for the diagnosis of endometriosis. Our case-control study included 284 patients and showed that plasma levels of GAS6 are significantly higher in patients with endometriosis compared to control patients. We calculated logistic regression models using GAS6, CA-125, and GAS6 together with CA-125, and added a series of clinical and lifestyle data collected before surgical diagnosis. A CA-125 model and a model including GAS6 and CA-125 showed the highest AUC values of 0.745 ± 0.04, while the model including CA-125, data on sport/recreation before surgery, and dysmenorrhea score reached an AUC of 0.767 ± 0.04. Our results indicate that GAS6 is increased in patients with endometriosis, but it cannot serve as a biomarker candidate. CA-125 GAS6 biomarker discovery endometriosis logistic regression odkrivanje bioloških označevalcev endometrioza logistična regresija true false true Angleški jezik Slovenski jezik Neznano 2026-04-14 14:39:59 2026-04-14 14:39:59 2026-04-15 03:57:41 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 29. 9. 2025; str. 1-16 iss. 17 [article no.] 8348 Vol. 26 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.2 1422-0067 10.3390/ijms26178348 250778883 RAZ_Pusic_Novak_Maja_2025.pdf RAZ_Pusic_Novak_Maja_2025.pdf 1 20E6F607201B71E4CA2E2173D9735DAB 3d9242bf8d35c4c811cad75a3d1f3c74d8500444cb4f02d080798b7369f4f06e 29e28245-37ff-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43197 https://www.mdpi.com/1422-0067/26/17/8348 1 0eff7dd0-37ff-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43196 Univerzitetni klinični center Ljubljana 0 0 0