20.500.12556/DiRROS-28949 Cerebrospinal fluid findings and their temporal pattern in patients with different clinical presentations of tick-borne encephalitis a cohort study Objectives: There is a lack of systematic data on cerebrospinal fluid (CSF) findings in the different clinical manifestations of tick-borne encephalitis (TBE) and according to the duration of neurological involvement. This study aims to evaluate and compare routine CSF parameters in TBE patients presenting with meningitis, meningoencephalitis, or meningoencephalomyelitis, and to assess temporal changes in CSF during the first 10 days after the onset of neurological symptoms. Methods: We analysed 15 CSF parameters in 717 consecutive adult patients hospitalized for TBE at the Department of Infectious Diseases, University Medical Centre Ljubljana, Slovenia. Among these patients, 230 (32%) had meningitis, 446 (62%) meningoencephalitis, and 41 (6%) meningoencephalomyelitis. Results: CSF findings differed significantly among the three clinical presentations. Leukocyte count, neutrophil proportion, protein levels, immunoglobulin concentrations (IgM, IgG, IgA), and intrathecal synthesis quotients were highest in meningoencephalomyelitis and lowest in meningitis. These differences remained largely significant after adjusting for confounding factors. CSF abnormalities were detectable from day one of neurological symptoms, peaked around days 4–5, and then stabilized or showed mild improvement. Neutrophils predominated during the first two days, followed by a predominance of lymphocytes and monocytes from day 3 onward. This pattern was consistent in meningitis and meningoencephalitis but less pronounced in meningoencephalomyelitis. Conclusions: Clinical manifestations of TBE exhibit distinct CSF profiles. Abnormalities are most pronounced in meningoencephalomyelitis and least in meningitis. These alterations appear early, peak within the first days, and then stabilize or improve, although this pattern is less predictable in meningoencephalomyelitis. tick-borne encephalitis meningitis meningoencephalitis meningoencephalomyelitis cerebrospinal fluid klopni meningoencefalitis možganska tekočina meningitis meningoencefalitis meningoencefalomielitis true false true Angleški jezik Slovenski jezik Neznano 2026-04-14 13:32:43 2026-04-14 13:32:43 2026-04-15 03:57:39 0000-00-00 00:00:00 2026 0 0 Nasl z nasl. zaslona; Opis vira z dne 28. 11. 2025; str. 729–740 iss. 2 Vol. 54 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 1439-0973 10.1007/s15010-025-02700-y 259088643 RAZ_Bogovic_Petra_2026.pdf RAZ_Bogovic_Petra_2026.pdf 1 2E94D4D749F6FA59CADB65DEDE531E48 c97c0e17c35f04e412ceb8ae34dd483c36ffe79a86018295c1a3db59a8d6b2da c7083866-37f5-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43181 Univerzitetni klinični center Ljubljana 0 0 0