20.500.12556/DiRROS-28917 Herpes simplex virus 1 encephalitis in first trimester of pregnancy a case report Encephalitis caused by herpes simplex virus 1 (HSV-1) has been described in pregnancy, but it’s rare, with less than 20 cases being described in peer-reviewed literature. Physiologic changes in immune response during pregnancy influence the course of HSV-1 encephalitis (HSVE) and predispose pregnant women to severe complications. We present a case of herpetic encephalitis in a 12-weeks pregnant patient. In our patient neurologic condition deteriorated despite early diagnosis, appropriate antiviral and antiepileptic treatment, and suppurative neurocritical care, respectively. Disease progression stopped and the patient’s condition improved after pregnancy termination. Improvement could be a consequence of multiple factors, including delayed therapeutic effect of antiviral treatment, the impact of intensive care management, seizure control, and the possibility of spontaneous recovery as part of the natural disease course, respectively. This case highlights the potential severity of HSV-1 in early pregnancy and underscores the importance of multidisciplinary management and individualized decision-making in complex clinical situations. herpes simplex virus encephalitis pregnancy virus herpes simplex encefalitis nosečnost true false false Angleški jezik Slovenski jezik Neznano 2026-04-14 09:25:46 2026-04-14 09:25:47 2026-04-15 03:57:34 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 14. 4. 2026; 4 str. issue 1 Vol. 2026 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.3 2090-6692 10.1155/crog/8743269 275093251 RAZ_Furlan_Matej_2026.pdf RAZ_Furlan_Matej_2026.pdf 1 0DDE80D23CA79B192FAEA069A87855E8 6b59a35c5d0bea94bfb0dc5192af688d360cb77f2512862dbba3b9d1f78fcbf2 42169eb4-37d3-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43129 https://onlinelibrary.wiley.com/doi/10.1155/crog/8743269 1 29401ce3-37d3-11f1-9cc3-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43128 Univerzitetni klinični center Ljubljana 0 0 0