20.500.12556/DiRROS-28889 Functional neurological disorder following COVID-19 results from a Large International Electronic Health Record Database Background: Following COVID-19, an increased risk of neurological and psychiatric sequelae has been reported. Viral illnesses commonly trigger functional neurological disorder (FND). However, mechanisms beyond immediate biological effects may contribute to FND after COVID-19. While FND cases have been observed after COVID-19, the overall risk and contributing factors remain unclear. In this retrospective cohort study, we compared the rates of FND post-COVID-19 to other respiratory tract infections (RTIs), assessed the influence of disease severity, and the characteristics of newly diagnosed patients. Methods: We used TriNetX, a global electronic health record network. In total, 2,740,094 COVID-19 cases and 1846 post-COVID-19 FND cases were analysed. We compared FND incidence between 2 weeks and 6 months after COVID-19 to other RTIs and across cohorts of varying COVID-19 severity. Characteristics of individuals with new diagnoses of FND and migraine following COVID-19 were compared. Results: The incidence of FND was higher in COVID-19 patients with records of hospitalisation (OR 2.165; 95% CI 1.691-2.773) and emergency department visits (OR 1.412; 95% CI 1.069-1.864). Incidence was higher following COVID-19 compared to other RTIs, both in the first 2 years of the pandemic (0.033 vs. 0.021%, OR 1.555, 95% CI 1.271-1.902) and subsequently (0.038 vs. 0.027%, OR 1.394, 95% CI 1.173-1.657). Medical, neurological, and psychiatric comorbidities were more common in newly diagnosed post-COVID-19 FND compared to migraine. Conclusions: New-onset FND appears more likely after COVID-19 than other RTIs. Both the severity of the triggering illness and pre-existing individual vulnerability may contribute to the development of FND. COVID-19 conversion disorder functional neurological disorder neuropsychiatric manifestations risk factors konverzijska motnja funkcionalna nevrološka motnja nevropsihiatrične manifestacije dejavniki tveganja true false true Angleški jezik Slovenski jezik Neznano 2026-04-10 15:15:29 2026-04-10 15:15:30 2026-04-11 03:54:50 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 5. 1. 2026; str. 1-10 issue 12 Vol. 32 Dec. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 1468-1331 10.1111/ene.70459 263346435 RAZ_Berlot_Rok_2025.pdf RAZ_Berlot_Rok_2025.pdf 1 F3A6AC715DFAD71C3F81DDB91D10ACE7 56cf5249501e5a915789db6c884d5aabbf1b264409218bade518746c21d184da 743ec9b5-34df-11f1-b941-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43075 https://onlinelibrary.wiley.com/doi/10.1111/ene.70459 1 5ac3ce92-34df-11f1-b941-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43074 Univerzitetni klinični center Ljubljana 0 0 0