20.500.12556/DiRROS-28868 Lipid-phase-modulated interactions of gold nanoparticles with supported vesicular and planar membranes The thorough understanding of the interactions between nanoparticles and lipid membranes has attracted major interest over the past few decades. This spans fundamental biophysics and biomechanics, as well as medical applications, where nanoparticles could serve as potential drug carriers. The influence of the lipid phase in these interactions has been studied to markedly less extent with respect to the nanoparticle size, shape and coating, as well as the presence of electric charge in either the nanoparticles or the membranes. Seeking to gain new insights into the lipid phase, we have systematically investigated the role of the liquid-disordered, the gel-ordered, as well as the seldom-studied ripple phases in modulating the interaction strength between nanoparticles and biomimetic membranes. Supported lipid vesicles and supported lipid bilayers of different composition and amount of electric charge, as well as spherical functionalized Au nanoparticles with and without charge have formed our experimental platform. The results, obtained by quartz crystal microbalance with dissipation monitoring and complemented by atomic force microscopy, reveal a strikingly different mechanistic picture of the interactions between the various lipid phases and types of nanoparticles. We demonstrate enhanced vesicle rupture in the case of stiffer membranes, consistent with recent theoretical studies, yet supported by limited existing experimental evidence. This work advances fundamental understanding of lipid-state-driven nanoparticle–membrane interactions. Such insight is essential, as dynamic changes in bilayer rigidity, composition, and surface charge determine how membranes and nanoparticles interact. supported lipid vesicles supported lipid bilayers gold nanoparticles lipid phase quartz crystal microbalance with dissipation monitoring (QCM-D) nanoparticle-membrane interactions podprti lipidni vezikli podprte lipidne dvoslojnice zlati nanodelci lipidna faza kvarčna mikrotehtnica z merjenjem disipacije (QCM) interakcije med nanodelci in membranami true false true Elsevier Nizozemska Angleški jezik Slovenski jezik © 2026 The Author(s). Neznano 2026-04-10 10:09:19 2026-04-10 10:09:20 2026-04-11 03:54:48 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Soavtorji: Marta Lavrič, Maja Cof, Slavko Kralj, Raj Kumar Sadhu, Miha Škarabot, Patricia Losada-Pérez, Aleš Iglič, George Cordoyiannis; Opis vira z dne 9. 4. 2026; str. 1-13 Vol. 264, [article no.] 115665 Aug. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2026-01-27 2026-03-29 2026-03-30 620.3 1873-4367 10.1016/j.colsurfb.2026.115665 274687491 https://www.sciencedirect.com/science/article/pii/S0927776526002535?via%3Dihub 1 95c86529-34b4-11f1-b941-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43030 RAZ_Bar_Laure_2026.pdf RAZ_Bar_Laure_2026.pdf 1 A789A60B8C0A3E2F48252ECB764B3188 46a6dea13d48489358d92ca546112067c53f744391e5f09bc54652da11bf6940 e2563c5e-34b4-11f1-b941-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=43032 Institut Jožef Stefan 0 0 0