20.500.12556/DiRROS-28839 Appendiceal neuroendocrine tumors in children and adolescents the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT) diagnostic and therapeutic recommendations Neuroendocrine tumors of the appendix, formerly known as carcinoid tumors, represent a rare entity. They are slow-growing tumors, characterized by an indolent clinical course. In pediatric patients, the 5-year overall survival is estimated to be 100% and the event-free survival slightly less than 100%, with only one reported case of local relapse to date. Nevertheless, a proportion of these patients still undergo a second surgery, mostly represented by right hemicolectomy with mesenteric lymphadenectomy, in consideration of the presence of certain risk factors (size >1.5 or 2 cm; tumors of the appendiceal base with or without suspicious residuals, mesoappendiceal invasion, lymphovascular invasion, serosal breach). This approach represents an overtreatment of patients with a benign clinical course regardless of the presence of risk factors and/or whether a second surgery is performed. National recommendations for diagnosis, treatment, and follow-up of neuroendocrine tumors of the appendix in pediatric age are available in France, Italy, and Germany, but international consensus is lacking. This review presents the internationally harmonized recommendations for the diagnosis and treatment of neuroendocrine tumors of the appendix in children and adolescents, established by the European Cooperative Study Group for Pediatric Rare Tumors group. appendiceal neuroendocrine tumors pediatric oncology diagnostic and therapeutic recommendations apendikularni nevroendokrini tumorji pediatrična onkologija diagnostična in terapevtska priporočila true false true Angleški jezik Slovenski jezik Neznano 2026-04-09 09:45:02 2026-04-09 09:45:02 2026-04-10 03:55:36 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 9. 4. 2026; 8 str. [article no.] 109451 Vol. 184 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-053.2:616-006 1532-7361 10.1016/j.surg.2025.109451 274631427 RAZ_Virgone_Calogero_2025.pdf RAZ_Virgone_Calogero_2025.pdf 1 16C01D8D9698A2C48CBBFC9FADB1E842 1074881caea6ecfdb545af963afe8088354362550c533a58cc3db029e42020df 41c2fc35-33e8-11f1-b941-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42977 https://www.surgjournal.com/article/S0039-6060(25)00303-4/fulltext 1 05bfb216-33e8-11f1-b941-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42976 Univerzitetni klinični center Ljubljana 0 0 0