20.500.12556/DiRROS-28824 Presepsin in neonatal sepsis a single-center evaluation in comparison to conventional markers Objective: Neonatal sepsis is a leading cause of morbidity and mortality in newborns. Timely and accurate diagnosis remains a challenge due to the nonspecific clinical signs and the limited sensitivity and specificity of conventional biomarkers such as C-reactive protein (CRP), procalcitonin (PCT), and white blood cell (WBC) count. Presepsin, a soluble CD14 subtype, has been proposed as a promising early marker of bacterial infection. This study aimed to assess the diagnostic value of serum presepsin in comparison with traditional inflammatory markers in neonates with suspected sepsis. Methods: In a prospective observational study conducted at a single tertiary care center, 18 neonates with clinical signs of sepsis were evaluated. The patients were divided into culture-proven (n=7) and culture-unproven (n=11) sepsis groups. Presepsin levels were measured using a chemiluminescent assay and compared to CRP, PCT, and WBC counts. Results: The median presepsin levels were higher in culture-proven cases (740 ng/L vs. 393 ng/L), but without statistical significance. Similar trends were observed for CRP and PCT, while WBC counts showed no diagnostic value. Conclusion: Although presepsin demonstrated potential as an early biomarker, its diagnostic performance in this small cohort was inconclusive. Combined use of presepsin with conventional markers and clinical evaluation may improve early sepsis diagnosis in neonates. neonatal sepsis presepsin inflammatory markers procalcitonin C-reactive protein neonatalna sepsa presepsin vnetni markerji prokalcitonin C-reaktivni protein true false true Angleški jezik Makedonski jezik Neznano 2026-04-08 13:23:34 2026-04-08 13:23:35 2026-04-09 03:51:22 0000-00-00 00:00:00 2026 0 0 str. 85-91 iss 1 Vol. 47 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.94:616.8-053.31 1857-9345 10.2478/prilozi-2026-0009 273739779 RAZ_Kavcic_Mojca_2026.pdf RAZ_Kavcic_Mojca_2026.pdf 1 A4C04A816CA3274A10558BC9B8988BE4 8949b325c8254b291b26115bb2b370090a2e307e09281ac9e39d61dbae16e47d 7dc77737-333d-11f1-b941-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42948 https://reference-global.com/article/10.2478/prilozi-2026-0009 1 6423e653-333d-11f1-b941-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42947 Univerzitetni klinični center Ljubljana 0 0 0