20.500.12556/DiRROS-28795 CAR T therapy in adult DLBCL patients in Slovenia evaluation of predictive scores for outcomes and adverse events CAR T cell therapy is a promising immunotherapy for hematologic malignancies, yet early prediction of outcomes and adverse events remains difficult, especially in small real-world cohorts. We retrospectively analyzed 14 adult patients with diffuse large B-cell lymphoma (DLBCL) treated with CAR T cells in Slovenia, assessing IL-6 increase rates and established predictive metrics including EASIX-C, CAR-HEMATOTOX, and IBPS on Day -5 (pre-lymphodepletion) and Day 0 (infusion). Contrary to our expectation, an inverse correlation was observed between the increase rate of IL-6 and the occurrence of severe cytopenias, indicating higher IL-6 increase rate leads to less severe cytopenias. The EASIX-C score showed higher predictive values when calculated on Day 0, contrary to the CAR-HEMATOTOX score, whose higher predictive values were observed on Day -5. The IBPS predictive values showed mixed results when comparing Day -5 to Day 0. We observed 50% response rate and 29% remission rate. The results highlight the utility of predictive scores, with unexpected findings on IL-6 suggesting further study is necessary. CAR T cell therapy adverse events diffuse large B-cell lymphoma hematologic malignancies celično zdravljenje CAR T neželeni učinki difuzni velikocelični limfom krvni raki true false true Angleški jezik Slovenski jezik Neznano 2026-04-07 15:13:36 2026-04-07 15:13:36 2026-04-08 03:47:44 0000-00-00 00:00:00 2026 0 0 str. 1-12 no. 1 Vol. 22 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2164-5515 10.1080/21645515.2026.2620889 267251459 RAZ_Srsen_Lucija_2026.pdf RAZ_Srsen_Lucija_2026.pdf 1 4C56CD2B9C3E090B355B49ABD11A56AC 75a1eb4e3365095bc8b66122fd4dcd413e8c740d69644051e31e105be699aaad b773eec1-3283-11f1-b7aa-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42884 https://www.tandfonline.com/doi/full/10.1080/21645515.2026.2620889 1 980c818d-3283-11f1-b7aa-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42883 Univerzitetni klinični center Ljubljana 0 0 0