20.500.12556/DiRROS-28785 Transcutaneous carbon dioxide therapy significantly accelerates diabetic foot ulcer healing a multicentre randomised controlled trial Background/Objectives: Diabetic foot ulcers (DFUs) represent common and severe complications of diabetes mellitus (DM). The aim of our parallel-group, open-label, superiority, multicentre randomised controlled trial (RCT) was to evaluate the effectiveness of transcutaneous gaseous carbon dioxide therapy (hereinafter CO2 therapy) in ulcer healing in patients with non-healing DFUs. Methods: A total of 115 participants (89 males and 26 females, aged 65.7 ± 10.9 years) with a non-healing DFU were randomised to the intervention (76 participants) and control (39 participants) group. Participants in the intervention group received standard of care, combined with CO2 therapies administered every weekday for four consecutive weeks. Participants in the control group received only standard of care. Results: After 4 weeks, 49 (64.5%) ulcers in the intervention group healed, compared with three (7.7%) in the control group (primary outcome). The percentage ulcer area reduction from baseline (secondary outcome) was significantly larger (p ≤ 0.001) in patients from the intervention group, with the median value 100% (18.4–100%), compared to the patients from the control group, with the median value 40% (−300–100%). Patients receiving CO2 therapy had 35.4-fold higher odds of ulcer healing versus controls (OR 35.4, 95% CI 6.68–187.53; p < 0.001), and in multivariate logistic regression, CO2 therapy remained independently associated with healing, while larger baseline ulcer area was associated with lower odds of healing (OR 0.654, 95% CI 0.438–0.977; p = 0.038). No adverse effects were reported. Conclusions: CO2 therapy significantly contributes to ulcer healing in patients with non-healing DFUs, with no observable adverse effects, demonstrating significant potential as an effective and safe complementary treatment of DFUs in conjunction with standard of care. transcutaneous CO2 therapy diabetic foot ulcer wound healing chronic wound transkutana terapija s CO2 razjeda diabetičnega stopala celjenje ran kronična rana true false true Angleški jezik Slovenski jezik Neznano 2026-04-07 13:28:15 2026-04-07 13:28:16 2026-04-08 03:47:41 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 25. 3. 2026; 12 str. iss. 2, [art. no.] 422 Vol. 14 Feb. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-001.4-036.1 2227-9059 10.3390/biomedicines14020422 272987651 RAZ_Frangez_Igor_2026.pdf RAZ_Frangez_Igor_2026.pdf 1 7C96D91CD7C94B9949714DEE176C3883 7caccd1488c438fb8269578dab91f14869efb228c3bd572293abe6a6eba50a98 03cab81d-3275-11f1-b7aa-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42865 https://www.mdpi.com/2227-9059/14/2/422 1 dffba6d8-3274-11f1-b7aa-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42864 Univerzitetni klinični center Ljubljana 0 0 0