20.500.12556/DiRROS-28737 The incidence of early recurrent venous thromboembolism a systematic review and meta-analysis Background: Patients with venous thromboembolism (VTE) receive anticoagulation for at least 3 months. To evaluate recurrence risk thereafter, some strategies include D-dimer testing after discontinuing anticoagulation, which raises concern about early recurrence. Objectives: To assess the incidence of recurrent VTE within 30 days after stopping anticoagulation. Methods: We conducted a systematic review of EMBASE, CENTRAL, and MEDLINE to identify controlled trials and cohort studies of adult noncancer patients with deep vein thrombosis of the leg and/or pulmonary embolism treated with anticoagulants for ≥3 months. The primary outcome was symptomatic VTE within 30 days. The risk of bias was assessed using a modified version of the Newcastle-Ottawa Scale. Pooled recurrence rates were calculated using fixed random-effects meta-analyses. Results: Of 42 studies, 24 (57%) provided data, encompassing 11,407 patients. Early recurrence occurred in 115 patients (1.01%), with a pooled incidence of 1.04% (95% CI, 0.8%-1.4%). Men had a risk similar to that of women (risk ratio, 1.2; 95% CI, 0.6-2.3; P = .7). Unprovoked VTE was associated with a 2.6-fold increase in risk (95% CI, 1.4-4.6; P < .001) compared with provoked VTE. Patients with deep vein thrombosis at presentation had a similar risk of recurrence compared with those with an incident pulmonary embolism (risk ratio, 0.6; 95% CI: 0.3-1.2; P = .1). Findings regarding age were inconsistent. None of the recurrences was fatal. The overall risk of bias was low. Conclusion: The incidence of early VTE recurrence after stopping anticoagulation is low. Temporarily discontinuing therapy to assess recurrence risk, therefore, appears safe and may aid in guiding treatment duration. anticoagulation early recurrence incidence meta-analysis venous thromboembolism antikoagulacija zgodnja ponovitev incidenca meta-analiza venska trombembolija true false true Angleški jezik Slovenski jezik Neznano 2026-03-31 13:10:15 2026-03-31 13:10:15 2026-04-01 03:58:43 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 26. 3. 2026; str. 1-9 iss. 1, [article no.] 103317 Vol. 9 Jan. 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2475-0379 10.1016/j.rpth.2025.103317 273221123 RAZ_Eischer_Lisbeth_2026.pdf RAZ_Eischer_Lisbeth_2026.pdf 1 B1EEBE2C6C1D60E4AE7CF68110714389 6891cc3685b3eae5d6170a730fed4d1392c4a38b39dd8a7fda98980b87a62772 57d23531-2cf2-11f1-9147-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42760 https://www.rpthjournal.org/article/S2475-0379(25)00641-7/fulltext 1 32e02aef-2cf2-11f1-9147-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42759 Univerzitetni klinični center Ljubljana 0 0 0