20.500.12556/DiRROS-28731 Impact of smoking status on mortality in STEMI patients undergoing mechanical reperfusion for STEMI insights from the ISACS–STEMI COVID-19 registry The so-called “smoking paradox”, conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS–STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history. myocardial infarction smoking paradox percutaneous coronary intervention COVID-19 mortality true false true Angleški jezik Ni določen Neznano 2026-03-31 12:21:42 2026-03-31 12:21:42 2026-04-01 03:58:41 0000-00-00 00:00:00 2022 0 0 Nasl. z nasl. zaslona; Opis vira z dne 24. 3. 2026; str. 1-13 issue 22, [article no.] 6722 Vol. 11 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 2077-0383 10.3390/jcm11226722 272745987 RAZ_De_Luca_Giuseppe_2022.pdf RAZ_De_Luca_Giuseppe_2022.pdf 1 4CDC26B1072FAFADCDE6CB174816980C cb7cc25520ec40b6d79000588bc093063efd855f64ddd5547ee6c139bdc97f38 8e3c3bbf-2ceb-11f1-9147-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42749 Univerzitetni klinični center Ljubljana 0 0 0