20.500.12556/DiRROS-28721 Better growth outcomes in GH-deficient children treated younger than 2 years of age Background: Limited data are available on the growth response to growth hormone (GH) treatment in very young children with GH deficiency (GHD). In the present analysis, we compared clinical outcomes after GH treatment in children with GHD aged <2 and ≥2 years at the start of GH treatment. Methods: We analysed pooled data from two observational studies of paediatric patients who received Norditropin® treatment: NordiNet® IOS (NCT00960128) and the ANSWER Program (NCT01009905). Patients with GHD, who remained pre-pubertal after 1 year of treatment, were grouped by age at treatment start (<2 years; ≥2 years). The primary effectiveness outcome was change in height standard deviation score (SDS) after 1 and 10 years. We also investigated the frequency of non-serious adverse drug reactions (ADRs), serious ADRs and serious adverse events (SAEs). Results: In total, 507 and 7,486 children initiated treatment at <2 and ≥2 years of age, respectively. Height SDS (mean change (SD) from baseline) improved after 1 year of treatment in both groups and was greater in children initiating treatment at <2 years than in those initiating treatment at ≥2 years (1.4 (1.2) and 0.75 (0.5), respectively); these findings were sustained after 10 years of treatment (3.2 (1.7) and 2.2 (1.3), respectively). SAEs were more frequent in children initiating treatment at <2 years vs ≥ 2 years (3.3 vs 0.67%, respectively). Conclusions: Children aged <2 years at GH treatment initiation had better height outcomes, but more SAEs, after 1 and 10 years of GH treatment compared to children starting GH at age ≥2 years. growth factors development/foetal nutrition pituitary paediatric endocrinology growth hormone therapy growth hormone deficiency multiple pituitary hormone deficiency clinical outcomes real-world data rastni faktorji razvojna/fetalna prehrana hipofiza pediatrična endokrinologija zdravljenje z rastnim hormonom pomanjkanje rastnega hormona pomanjkanje več hipofiznih hormonov klinični izidi podatki iz resničnega sveta true false true Angleški jezik Slovenski jezik Neznano 2026-03-31 10:06:33 2026-03-31 10:06:33 2026-04-01 03:58:39 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 31. 3. 2026; str. 1-13 iss. 9 Vol. 14 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.4 2049-3614 10.1530/EC-25-0493 273675011 RAZ_Rohrer_Tilman_R._2025.pdf RAZ_Rohrer_Tilman_R._2025.pdf 1 11C332415266207CD65BFA8B105A0212 3a3f3114a427db504ef62532dedbf38af273979edc1c37b5cfed28565339424a ce28ee4e-2cd8-11f1-9147-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42728 https://ec.bioscientifica.com/view/journals/ec/14/9/EC-25-0493.xml 1 88e3c402-2cd8-11f1-9147-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42727 Univerzitetni klinični center Ljubljana 0 0 0