20.500.12556/DiRROS-28634 Aminoglycoside antibiotics as first-line treatment of acute appendicitis and cholecystitis We analyzed the efficacy and safety of aminoglycosides in a retrospective study of 415 patients with acute appendicitis and 277 patients with acute cholecystitis. The following variables increased the incidence of postoperative complications, defined as surgical site infection, recurrent intraabdominal infection, non-infectious post-operative complication, or death: age (p = 0.016 and 0.011), kidney disease (p = 0.019 and <0.001), and ASA Score (p < 0.001). The type of antibiotic therapy did not have a statistically significant effect on the incidence of postoperative complications in patients with acute appendicitis and cholecystitis (p = 0.561 and 0.547, respectively). A linear regression model showed a higher complication rate in patients with kidney disease (p = 0.014) and neoplasms (p = 0.013); the type of antibiotic therapy did not have a significant effect on the outcome (p = 0.765). There was no statistically significant difference in the post-treatment levels of creatinine in patients treated with aminoglycosides (gentamicin 3 mg/kg once daily) and in those who received other antibiotics (p = 0.75). aminoglycoside antibiotics antimicrobial resistance intraabdominal infection nephrotoxicity risk factors aminoglikozid antibiotiki protimikrobna odpornost intraabdominalna okužba nefrotoksičnost dejavniki tveganja true false true Angleški jezik Slovenski jezik Neznano 2026-03-26 15:08:58 2026-03-26 15:08:58 2026-03-28 03:53:33 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 8. 8. 2024; str. 307-316 iss. 4 Vol. 37 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-07 1973-9478 10.1080/1120009X.2024.2381158 203877379 RAZ_Setinc_Lucka_2025.pdf RAZ_Setinc_Lucka_2025.pdf 1 1AA2C4CFCC4A87B38F15CBE10DBDF178 6f614df6318192acb85ca0422cb36572e6b0be5c1d2667ad4c71c93df88dbaff 837cc767-291d-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42548 https://www.tandfonline.com/doi/epdf/10.1080/1120009X.2024.2381158?needAccess=true 1 56bdb859-291d-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42547 Univerzitetni klinični center Ljubljana 0 0 0