20.500.12556/DiRROS-28630 Segmental myocardial strain in myocarditis in young adults natural variability versus myocarditis signal Introduction: Myocardial segmental peak strain (pkS) is used in detection and characterization of myocarditis; however, its clinical diagnostic values are inconclusive. To reveal potential causes of positive and negative study results and evaluate the diagnostic potential of pkS, we quantified its natural variability and compared it to the change in pkS caused by myocarditis. Methods: The study included 34 patients (sex: 29 M, age: 30 ± 7.5 years) with diagnosed myocarditis which underwent two-dimensional speckle tracking echocardiography (2D-STE) in three apical echocardiographic planes at the time of diagnosis (M0) and 6 months (M6) following treatment. In total, 18 longitudinal segmental strain patterns were extracted at each session and a pkS was found as a minimum strain value during systole. The average natural variability (▫$\mathrm{\overline{NVm}}$▫) was calculated from sector values of all unique pkS absolute differences separately at M0 and M6, and myocarditis signal (▫$\mathrm{\overline{MC}}$▫) was calculated from pkS difference in the same patient between M6 and M0. A signal-to-noise ratio was calculated as (▫$\mathrm{\overline{MC}/\overline{NV(M6)}}$▫). Results: We found that the average pkS at M0 and M6 were different (−19% ± 5% and −20% ± 5%, p < 0.05), and the difference was largest around the basal-posterior segment. There was no difference in (▫$\mathrm{\overline{NV}}$▫) between M0 and M6 (5.1% ± 4.2% and 5.0% ± 4.2%, p > 0.05), but they were both significantly larger than (▫$\mathrm{\overline{MC}}$▫) (−1.3% ± 5.3%, p < 0.05). The average signal-to-noise ratio was 0.3, and it was largest in the basal-lateral region and lowest in the anterior-septal region. Conclusion: We found that natural variability in pkS is significantly larger than the change of pkS due to myocarditis. Thus, information about inflammation severity and location from pkS alone needs further investigation. medicine heart myocarditis medicina bolezni srca miokarditis true false true Angleški jezik Slovenski jezik Neznano 2026-03-26 13:49:46 2026-03-26 13:49:46 2026-03-28 03:53:05 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 2. 10. 2024; str. 25-31 iss. 1 Vol. 12 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.12 2054-6750 10.1002/sono.12474 209946371 RAZ_Kirn_Borut_2025.pdf RAZ_Kirn_Borut_2025.pdf 1 2CDDB9D6E194BC6B18682EAFFCB4241A 61f57c9d5bb2f5c131aac69915aa9f41c7c4c3f29f9dea70d3ca20f49b58346c 7a29d150-2912-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42540 https://onlinelibrary.wiley.com/doi/10.1002/sono.12474 1 4562fde9-2912-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42539 Univerzitetni klinični center Ljubljana 0 0 0