20.500.12556/DiRROS-28619 The application of ultrasound sarcopenia index in sarcopenic population Background: Aging leads to progressive motor system decline, which can result in sarcopenia, defined as the age- related loss of muscle mass and function. Architectural changes, epitomized by a decrease in fascicle length (Lf) and muscle thickness (MT), provide a useful signature of sarcopenia. Their ratio (Lf/MT), named ultrasound sarcopenia index (USI), is a new parameter proposed for evaluating changes in muscle geometric proportions associated with muscle atrophy but lacks application in a sarcopenic population. This study aimed to explore vastus lateralis USI in a sarcopenic population. Methods: In a sample of 139 older adults (54% females), recruited from Italy and Slovenia, we assessed muscle architecture using ultrasound imaging to measure Lf, MT, pennation angle (PA), and USI. We assessed handgrip strength, sit-to-stand test, and physical performance with timed up-and-go and gait speed. Appendicular lean mass was assessed with dual x-ray absorptiometry. Sarcopenia was classified using the EWGSOP2 and SDOC classifications. Results: Sarcopenia prevalence was 15.1% and 30.9% when classified by the EWGSOP2 and SDOC classifications, respectively. Differences in muscle architecture were observed between sarcopenic and non-sarcopenic groups, with MT showing the largest effect size (Cohen's d EWGSOP2: 0.86; SDOC:0.77). USI was higher in sarcopenic compared to non-sarcopenic individuals classified with EWGSOP2 (5.33 ± 1.30 vs 4.59 ± 0.94, p = .011, Cohen's d:0.69), confirming its sensitivity in detecting sarcopenia. Conclusion: We showed that increased USI values are associated with sarcopenia. This study shows USI as a sensitive, non-invasive marker for sarcopenia classification, supporting its use in clinical screening and monitoring of muscle changes in older adults. muscle architecture aging muscle quality muscle function mišična arhitektura staranje mišična kakovost mišična funkcija true false true Angleški jezik Slovenski jezik The authors Neznano 2026-03-26 09:11:56 2026-03-26 09:11:57 2026-03-27 04:14:47 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Soavtorji: Fabio Sarto, Marco Narici, Boštjan Šimunič; Opis vira z dne 26. 3. 2026; 6 str. [article no.] ǂ113109 Vol. 217 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2026-01-01 612.7 1873-6815 10.1016/j.exger.2026.113109 273106435 26-03-26-101-Pus-273106435.pdf 26-03-26-101-Pus-273106435.pdf 1 C7F292B27CFB1C46519642CACCA94FFB 0c91d0b400868d6a5a13bc031f7bcc8cd0d942ae15494b3ebd47b02848efd78b 8efdea9c-28eb-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42515 https://www.sciencedirect.com/science/article/pii/S0531556526000872?via%3Dihub 1 77be3dff-28eb-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42514 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0