20.500.12556/DiRROS-28614 SIRT1 rs7069102 polymorphism confers increased risk of diabetic retinopathy in T2DM Background: The incidence and prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide recently. Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, and it is the leading cause of blindness and visual impairment. Sirtuin 1 (SIRT 1) is a NAD+-dependent deacetylase and is involved in stress responses such as hypoxic and genotoxic stress, inflammation and heat shock. Tumor necrosis factor α (TNF-α) is an important inflammatory mediator that is involved in the pathogenesis of T2DM. The purpose of our study was to investigate the relationship between the SIRT1 rs7069102 polymorphism and TNF- α rs1800629 polymorphisms and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). Materials and methods: We analyzed 1554 Slovenian (Caucasian) patients with T2DM of at least 10 years' duration, stratifying them into two groups: 577 patients with diabetic retinopathy (DR) and 977 patients without DR. Genotyping of SIRT1 rs7069102 and TNF-α rs1800629 polymorphisms was performed using the StepOne real-time PCR System with TaqMan SNP Genotyping Assays. Results and conclusions: A significant difference in the distribution of SIRT1 rs7069102 genotypes and alleles was observed between the groups. Under the dominant inheritance model, patients with CC or CG genotypes were more likely to develop DR than those with the GG genotype (OR = 1.30; 95% CI = 1.02-1.65; p = 0.036). No significant association was found between TNF-α rs1800629 and DR. SIRT1 T2DM TNF-α diabetic retinopathy rs1800629 rs7069102 diabetična retinopatija true false true Angleški jezik Slovenski jezik Neznano 2026-03-26 08:30:45 2026-03-26 08:30:45 2026-03-27 04:14:46 0000-00-00 00:00:00 2026 0 0 Soavtorji: Jernej Letonja, Mojca Globočnik Petrovič, Ana Peterlin, Ema Šuligoj, Stella Stare, Daniel petrovič; Nasl. z nasl. zaslona; Opis vira z dne 9. 3. 2026; str. 1-11 iss. 2, [article no.] 221 Vol. 17 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.2 2073-4425 10.3390/genes17020221 270948355 RAZ_Besic_Melina_2026.pdf RAZ_Besic_Melina_2026.pdf 1 F891477FA162103601B323ED0003D991 14a27f7bbf07ccf348a2c261c6b085630181a2d40b0ce5f9fa1639d5875bfa97 e085e541-28e5-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42507 https://www.mdpi.com/2073-4425/17/2/221 1 b577e16a-28e5-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42506 Univerzitetni klinični center Ljubljana 0 0 0