20.500.12556/DiRROS-28585 Gender difference in the effects of COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI results of the ISACS-STEMI COVID-19 registry Background. Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry. Methods. This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March–June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time ≥ 12 h and door-to-balloon ≥ 30 min) and in-hospital or 30-day mortality. Results. We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI: 0.825–0.861, p < 0.0001). We did not find a significant gender difference in the effects of the COVID-19 pandemic on the numbers of STEMI patients, which were similarly reduced from 2019 to 2020 in both groups, or in the mortality rates. Compared to prepandemia, 30-day mortality was significantly higher during the pandemic period among female (12.1% vs. 8.7%; adjusted HR [95% CI] = 1.66 [1.31–2.11], p < 0.001) but not male patients (5.8% vs. 6.7%; adjusted HR [95% CI] = 1.14 [0.96–1.34], p = 0.12). Conclusions. The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures similarly observed in both genders. Furthermore, we observed significantly increased in-hospital and 30-day mortality rates during the pandemic only among females. gender COVID-19 mortality STEMI spol COVID-19 smrtnost STEMI true false true Angleški jezik Slovenski jezik Neznano 2026-03-24 14:50:49 2026-03-24 14:50:49 2026-03-27 03:53:40 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Opis vira z dne 24. 3. 2026; 15 str. iss. 3, [article no.] 896 Vol. 12 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.12 2077-0383 10.3390/jcm12030896 272844291 https://www.mdpi.com/2077-0383/12/3/896 1 78de1d48-2788-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42443 RAZ_De_Luca_Giuseppe_2023.pdf RAZ_De_Luca_Giuseppe_2023.pdf 1 D2C86B3C06261FB009DB332422890150 e441cb48cccb17fc75aebe7d533d927f220772dca1281d335393af188f1cc272 aab418da-2788-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42445 Univerzitetni klinični center Ljubljana 0 0 0