20.500.12556/DiRROS-28546 Mapping EQ-5D-5L utility scores from the Severe Asthma Questionnaire in the SHARP CRC Registry Background Severe asthma imposes a substantial burden on individuals’ health-related quality of life (HRQoL), which might not be fully captured by generic instruments. The Severe Asthma Questionnaire (SAQ) is a validated disease-specific HRQoL instrument capturing the unique lived experience of people with severe asthma. However, the SAQ does not generate preference-based utility values required for health economic evaluations. This study aimed to develop and validate mapping algorithms from the SAQ to the EuroQol (EQ)-5D-5L, enabling estimation of utility values when EQ-5D data are unavailable. Methods We used baseline and 6-month data from the longitudinal, multicentre SHARP Burden of Asthma study, including adults with severe asthma across 7 European countries. Direct mapping (ordinary least squares and beta-mixture regression models) using the UK value set and indirect mapping (ordered probit regression models) were developed with baseline data to predict EQ-5D-5L utility values from SAQ scores. Performance was assessed via mean absolute error (MAE), root mean square error (RMSE), and R2, with 6-month data used for validation. Results Data from 327 patients were included. The beta-mixture model using SAQ subscales marginally outperformed the other models in the development set (MAE=0.090, RMSE=0.129, R2=0.704), whereas in the validation set the ordered probit regression model showed the best predictive performance (MAE=0.106, RMSE=0.151, R2=0.589). Conclusions Direct mapping with beta-mixture regression showed good overall performance, aligning with prior studies. Indirect mapping may be advantageous in settings requiring flexibility across EQ-5D-5L value sets. These findings demonstrate that EQ-5D-5L utility values can be reliably estimated from the SAQ, supporting use of the instrument in health-economic analyses. questionnaires quality of life health economic evaluation patient registries vprašalniki kakovost življenja zdravstveno-ekonomske analize registri bolnikov true false true Angleški jezik Slovenski jezik Neznano 2026-03-23 14:13:11 2026-03-23 14:13:11 2026-03-26 04:08:10 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 9. 3. 2026; str. 1-9 article no. ǂ108749 Vol. 255 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.248-036.8:519.23 1532-3064 10.1016/j.rmed.2026.108749 270906627 RAZ_Meulmeester_Fleur_L._2026.pdf RAZ_Meulmeester_Fleur_L._2026.pdf 1 D8415EB671DFE63169538B3FA5472E36 e60fc206c499bfb0a7e120e8e2aa39fe69216a117a5dc1a2f09c61f22fb570c3 398d8c36-26ba-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42348 https://www.sciencedirect.com/science/article/pii/S0954611126001174 1 0e548729-26ba-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42347 https://www.resmedjournal.com/article/S0954-6111(26)00117-4/fulltext 1 0dccb12a-26ba-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42346 Univerzitetni klinični center Ljubljana 0 0 0