20.500.12556/DiRROS-28504 IL-6 as an integrative biomarker of residual inflammation and visceral adiposity in psoriasis a VAI threshold-dependent model Introduction: Psoriatic patients are frequently exposed to residual inflammation and visceral obesity, two factors that synergistically increase cardiometabolic risk. Methods: We evaluated IL-6 as a potential integrative biomarker linking these pathways in a cross-sectional study including 80 patients with well-controlled skin disease and 20 matched healthy controls. Serum IL-6 was measured by ELISA, and visceral adiposity estimated using the Visceral Adiposity Index (VAI). Results: Psoriatic patients displayed significantly higher IL-6 than controls (38.1 pg/mL [35.5–41.3] vs. 21.4 pg/mL [19.5–33.4]; p<0.001). A distinct VAI threshold of 1.3 was identified, above which IL-6 levels rose steeply until VAI 2.2 and then plateaued. Patients with VAI ≥1.3 had markedly higher IL-6 and pro-inflammatory cytokines than those below this cutoff. Random forest regression confirmed IFN-γ, IL-1β, IL-12p70, and IL-17 as dominant predictors of IL-6, while HbA1c, FIB-4, and treatment contributed minimally. Discussion: These findings suggest that IL-6 elevation in psoriasis primarily reflects cytokine-driven residual inflammation, with non-linear amplification once visceral adiposity exceeds a critical threshold. The threshold-dependent IL-6 dynamic highlights a clinically meaningful inflection point, integrating residual inflammation and visceral fat dysfunction, and may guide early cardiometabolic risk stratification and intervention. Prospective validation is warranted. interleukin-6 psoriasis visceral adiposity index systemic inflammation obesity true false true Angleški jezik Ni določen Neznano 2026-03-23 11:00:09 2026-03-23 11:00:09 2026-03-26 04:01:01 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 22. 12. 2025; str. 1-7 article no. ǂ1699343 Vol. 16 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 1664-3224 10.3389/fimmu.2025.1699343 262509827 RAZ_Merzel_Sabovic_Eva_Klara_2025.pdf RAZ_Merzel_Sabovic_Eva_Klara_2025.pdf 1 4C023B732BABD9C4177D9A73CB1A4060 f9012831c73e0119e2f88d5000c0e9c19cfdb9972654680c1c3468c0a6bbc58b 39c9aaf8-269f-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42264 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1699343/full 1 147ac641-269f-11f1-aa40-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42263 Univerzitetni klinični center Ljubljana 0 0 0