20.500.12556/DiRROS-28454 Clinical manifestations of Lyme borreliosis in Europe Burden of Lyme disease study (BOLD), 2021–2022 Lyme borreliosis (LB), the most common European tick-borne disease, can manifest as an erythema migrans (EM) rash or as disseminated LB. The prospective Burden of Lyme Disease (BOLD) study evaluated the frequency of LB clinical manifestations, including signs, symptoms, and treatment patterns in 14 healthcare practices in endemic regions of six European countries: the Czech Republic, Germany, Poland, Slovakia, Slovenia, and Sweden. Between April 2021 and December 2022, patients with suspected LB were evaluated using predefined case definitions that were applied by investigators to identify medically attended LB cases. Enrolled cases were interviewed about their symptoms. Among the 797 LB cases, 615 (77.2%) had EM and 182 (22.8%) had disseminated disease; 154 of the disseminated cases had Lyme arthritis (LA), five had Lyme neuroborreliosis, and three had Lyme carditis. Geographically, the proportion of disseminated disease varied by country, from 1.1% in Slovenia to 78.0% in Slovakia. Overall, 76.3% of all LB cases in Slovakia were LA. Antibiotic use varied by country, although every country prescribed doxycycline. The frequency of LB manifestations varied substantially between countries. EM was the most common manifestation in all countries except Slovakia, where LA was most common. This study underscores the need for improved prevention strategies. burden of disease clinical manifestations disseminated disease Europe Lyme borreliosis Lyme Disease breme bolezni klinične manifestacije diseminirana bolezen Evropa lymske borelioza lymska bolezen true false true Angleški jezik Slovenski jezik Neznano 2026-03-20 08:44:47 2026-03-20 08:44:47 2026-03-26 03:47:07 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 20. 3. 2026; str. 1-22 issue 3, [article no.] 327 Vol. 15 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.9 2076-0817 10.3390/pathogens15030327 272372227 RAZ_Halsby_Kate_2026.pdf RAZ_Halsby_Kate_2026.pdf 1 E6F76800EC27CD6CE7254EE8A68201FB cf7cb59afc9d18843df923efe53fa8abcb5fad96112ab368a1c1dee94c98e9a4 e26bcd0c-2430-11f1-b469-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42153 https://www.mdpi.com/2076-0817/15/3/327 0 f01d0a15-2430-11f1-b469-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42154 Univerzitetni klinični center Ljubljana 0 0 0