20.500.12556/DiRROS-28415 Clinical factors in SARS-CoV-2 antibody response in unvaccinated mothers Objectives: Understanding the clinical factors influencing the SARS-CoV-2 antibody response during and after pregnancy is critical for optimizingmaternal care and vaccination strategies. This prospective cohort study aimed to evaluate associations between maternal clinical characteristics and SARS-CoV-2-specific IgG and IgA antibody levels at delivery and 42 days postpartum in unvaccinated pregnant women. Methods: A total of 387 pregnant women with confirmed SARS-CoV-2 infection during pregnancy were included. SARSCoV- 2 infectionwas confirmed using real-time RT-PCR. Clinical data, including age, body mass index (BMI), smoking status, pre-existing morbidities, and obstetric complications, were recorded. SARS-CoV-2-specific IgG and IgA antibodies were quantified using ELISA at delivery and 42 days postpartum. Results: Higher preconception BMI significantly correlated with increased odds of detecting IgG and IgA antibodies at both delivery and postpartum assessments (p<0.05), independently ofmaternal age and chronic diseases.Women without chronic systemic diseases exhibited lower antibody levels at delivery, whereas smokers had significantly lower odds of IgG antibody presence at delivery. Additionally, preexisting cardiovascular diseases were associated with reduced antibody presence at six weeks postpartum. Other clinical parameters did not show significant associations. Conclusions: Preconception BMI and pre-existing systemic diseases may modulate SARS-CoV-2 antibody responses in pregnant women. These clinical factors should inform assessments of maternal and neonatal infection risks and guide vaccination strategies in pregnant populations. Further research is needed to elucidate the mechanisms underlying these associations. SARS-CoV-2 IgG antibodies IgA antibodies pregnancy body mass index comorbidity postpartum period true false true Angleški jezik Ni določen Neznano 2026-03-18 14:45:27 2026-03-18 14:45:27 2026-03-25 03:55:39 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 2. 12. 2025; str. 173–182 issue 1 Vol. 54 2026 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.2/.7 1619-3997 10.1515/jpm-2025-0349 259540227 RAZ_Druskovic_Mirjam_2026.pdf RAZ_Druskovic_Mirjam_2026.pdf 1 AC6AEA4819DFA9DBD3A11C898F7008F8 1bc10479e98a4b8b07668841ca5b528a5a67407fd85961a6104df3a3e3e55bbb de67c4d0-22d0-11f1-a33f-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42042 https://www.degruyterbrill.com/document/doi/10.1515/jpm-2025-0349/html 0 e9c5dea0-22d0-11f1-a33f-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=42043 Univerzitetni klinični center Ljubljana 0 0 0