20.500.12556/DiRROS-28371 A comparison of transcatheter aortic valve prosthesis platforms Myval, Sapien, and Evolut in severe symptomatic aortic stenosis and low-moderate risk patients Background This article compares the real-world performance and safety of the three transcatheter aortic valve implantation (TAVI) platforms: Myval, Sapien, and Evolut in patients with severe symptomatic aortic stenosis and low to moderate surgical risk. Patients and methods Between September 2019 and September 2023, 1053 TAVI procedures were performed in the University Medical Centre Ljubljana, Slovenia. We used propensity-score match analysis to compare the Myval, Sapien, and Evolut platforms. 180 patients were enrolled in the propensity-score matching study, 60 for each platform. The study endpoints included haemodynamic outcomes compared to baseline, in-hospital clinical safety outcomes, and all-cause mortality at 30 days and one year. Results Changes in peak aortic valve velocity, mean aortic gradient, effective orifice area, and left ventricular ejection fraction were comparable between the platforms. After propensity score matching (tri-match), the rates of stroke (3.4% vs. 3.4% vs. 0.0%, p = 0.548), life-threatening bleeding (1.7% vs. 1.7% vs. 1.7 %), periprocedural myocardial infarction (3.3% vs. 0.0% vs. 0.0%, p = 0.330), postprocedural permanent pacemaker implantation rate (11.9% vs. 10.2% vs. 15.0%, p = 0.719), all-cause mortality at 30 days (3.3% vs. 5.0% vs. 3.3%; p = 1.000) and at 1 year (8.3% vs. 8.3% vs. 10.0%, p = 0.934) were comparable between the Myval, Sapien, and Evolut series, respectively. 2 cases of moderate paravalvular regurgitation were reported, one in Myval, and one in Sapien series. Conclusions The tri-match analysis of the real-world aortic stenosis patients with low to moderate surgical risk treated with the Myval, Sapien, and Evolut series showed comparable performance, safety, efficacy, and survival. transcatheter aortic valve implantation aortic stenosis real-world comparison perkutana zamenjava aortne zaklopke aortna stenoza true false true Angleški jezik Slovenski jezik Neznano 2026-03-16 09:04:37 2026-03-16 09:04:37 2026-03-24 03:50:04 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 16. 3. 2026; str. 498-509 no. 4 Vol. 59 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.126 1581-3207 10.2478/raon-2025-0046 271727107 RAZ_Bunc_Matjaz_2025.pdf RAZ_Bunc_Matjaz_2025.pdf 1 C7EDF056CDA87CFE7B1633FD507114A7 aaa4e77cab00b75f364368bf804ab2af269f7d11ba793c790c3448eb2e5d5722 f439f1b6-210e-11f1-a455-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41942 https://reference-global.com/article/10.2478/raon-2025-0046 1 c8482e97-210e-11f1-a455-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41940 Univerzitetni klinični center Ljubljana 0 0 0