20.500.12556/DiRROS-28121 Hemoperfusion with CytoSorb® in pediatric patients a monocentric case series Background: Pro- and anti-inflammatory cytokines help regulate the inflammatory response. A cytokine storm is a dysregulated cytokine response associated with sepsis and other conditions that result in a hyper-inflammatory state. Extracorporeal cytokine adsorption has the potential to restore a balanced inflammatory response. Hemoperfusion with CytoSorb® (CS) appears to be a short-term mode of treatment of sepsis in both adults and children. Objective: We present a case series of eight critically ill children involving the use of hemoperfusion with CS at the University Medical Center Ljubljana to treat clinically manifested cytokine storm. Results: In our preliminary experience, it was applied without complication in five children weighing more than 10 kg, who all survived. The effect of age on complications regarding CS treatment is unclear, yet in our case series, all three patients weighing less than 10 kg died of their disease. Conclusions: In our preliminary experience, cytokine adsorption with CS remains a potential adjunctive treatment for cytokine storm in critically ill children. CytoSorb hemoperfusion hemoadsorption child neonate sepsis cytokine storm true false true Angleški jezik Ni določen Neznano 2026-03-10 13:34:08 2026-03-10 13:34:08 2026-03-11 03:59:21 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 22. 7. 2025; str. 1-10 iss. 21 Vol. 13 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-053.2 2077-0383 10.3390/jcm13216587 243348483 RAZ_Rihar_Eva_2024.pdf RAZ_Rihar_Eva_2024.pdf 1 0FAEBBDB25CEDA5BF6BC06DB8DBADD98 f4e09cfc45b3b53c5a976a94242e0235bef3daa3e6a4c267a41d7406c47a04a0 955882c9-1c7d-11f1-acf8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41566 https://doi.org/10.3390/jcm13216587 0 a35a80aa-1c7d-11f1-acf8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41567 Univerzitetni klinični center Ljubljana 0 0 0