20.500.12556/DiRROS-28114 Novel perspectives of testosterone therapy in men with functional hypogonadism Introduction In the past decade, there has been a significant augmentation in the corpus of evidence pertaining to functional hypogonadism. Despite this, prevailing clinical guidelines continue to advise against the universal screening for hypogonadism in middle-aged and elderly males. Findings Numerous randomized controlled trials have scrutinized the effects of testosterone therapy in males afflicted with type 2 diabetes and/or obesity. However, these guidelines uniformly assert that lifestyle modifications and weight reduction should be the primary intervention strategies in overweight and obese males, relegating testosterone therapy to a secondary, selective option. It is extensively documented that testosterone therapy can yield substantial improvements in various metabolic parameters as well as ameliorate symptoms of erectile dysfunction. Moreover, recent studies have demonstrated the potential of testosterone therapy in reversing type 2 diabetes in males with low-normal testosterone levels who are at elevated risk for this condition, in comparison to the outcomes achievable through lifestyle modifications alone. Conclusion This focused review article aims to present a comprehensive update on the latest data concerning the innovative aspects of testosterone therapy in males with functional hypogonadism, particularly in the context of type 2 diabetes and/or obesity. Additionally, it will delve into the cardiovascular safety of such interventions within this high-risk demographic, with a special emphasis on insights gleaned from the TRAVERSE trial. hypogonadism testosterone men hypogonadism true false true Angleški jezik Ni določen Neznano 2026-03-10 12:49:10 2026-03-10 12:49:10 2026-03-11 03:59:17 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 13. 7. 2025; 14 str. no. 1, [article no.] 2296460 Vol. 27 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.4 1473-0790 10.1080/13685538.2023.2296460 242345987 RAZ_Groti_Antonic_Kristina_2024.pdf RAZ_Groti_Antonic_Kristina_2024.pdf 1 E19820BEF304B2ADAEF243197CEC49D0 fb14e491a4fbdb0a4e24a48934fadef12bb6022ca97a9ae9e392a0792efa7576 5a1b4ed4-1c77-11f1-acf8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41553 https://www.tandfonline.com/doi/full/10.1080/13685538.2023.2296460 1 2735c52f-1c77-11f1-acf8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41552 Univerzitetni klinični center Ljubljana 0 0 0