20.500.12556/DiRROS-28080 Indolent mastocytosis and bone health molecular mechanisms and emerging treatment options Mastocytosis is a heterogeneous group of disorders, distinguished by the monoclonal proliferation of mast cells (MCs) in one or more organs. While cutaneous mastocytosis (CM) is restricted to the skin, systemic mastocytosis (SM) presents with high MC infiltration of various organs. Indolent systemic mastocytosis (ISM) is the most common form in individuals with adult-onset of the disease. Bone health impairment is present in the vast majority of patients, ranging from osteoporosis to osteosclerosis, often presenting with fragility fractures. In this review, we comprehensively examine the impact of ISM on bone health, with particular emphasis on the molecular and cellular mechanisms underlying skeletal involvement, the clinical heterogeneity of bone manifestations, and the limitations of current diagnostic tools, while also evaluating emerging therapeutic strategies that target both MC activity and bone remodeling pathways. systemic mastocytosis indolent systemic mastocytosis bone health sistemska mastocitoza indolentna sistemska mastocitoza zdravje kosti true false true Angleški jezik Slovenski jezik Neznano 2026-03-09 14:36:31 2026-03-09 14:36:31 2026-03-11 03:41:44 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 12. 6. 2025; str. 1-18 iss. 12, [article no.] 5649 Vol. 26 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.4 1422-0067 10.3390/ijms26125649 239211523 RAZ_Jankovski_Lucia_2025.pdf RAZ_Jankovski_Lucia_2025.pdf 1 811ED06EA2C7BAACB7DFA7A9C71EDBA4 379805470f5efcccd7a0826ff3068c43f07885aefd8d1cd18a10b7972a3568cd 3e2886db-1bbd-11f1-b779-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41477 https://www.mdpi.com/1422-0067/26/12/5649 1 fcc46a15-1bbc-11f1-b779-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41476 Univerzitetni klinični center Ljubljana 0 0 0