20.500.12556/DiRROS-28056 Iatrogenic cerebral amyloid angiopathy two cases linked to childhood cadaveric dural transplantation for different intracranial pathologies, diagnosed using the simplified Edinburgh computed tomography criteria Background: Cerebral amyloid angiopathy (CAA) is an age-related condition marked by amyloid-β (Aβ) accumulation in the small cerebral vessels. Iatrogenic cerebral amyloid angiopathy (iCAA) is a distinct form of CAA in younger patients with a history of cranial surgeries involving cadaveric dural transplants. Both iCAA and CAA are linked to recurrent lobar intracerebral hemorrhage (ICH). This article highlights iCAA as a distinct variant, discussing the possibility of using simplified Edinburgh computed tomography (CT) criteria as a possible diagnostic tool for CAA and carefully considering plausible childhood surgery, with the risk of Aβ transmission through dural grafts in all, especially middle-aged patients. Case Description: We present two cases of iCAA in a 46-year-old female and a 52-year-old male who suffered recurrent spontaneous lobar ICHs. The CAA was diagnosed using the simplified Edinburgh CT criteria, leading to further investigations into the underlying pathology. Based on their age, iCAA was suspected, and only after a meticulous search of the hospital documentation it was discovered that they both underwent cranial surgeries in childhood involving cadaveric dural grafts. The diagnosis of iCAA was established using the proposed diagnostic criteria by Banerjee et al. and later confirmed by pathological examination. Conclusion: Our paper emphasizes the simplified Edinburgh criteria as a potential yet preliminary diagnostic tool for iCAA, while also highlighting the long-term risks of iatrogenic amyloid transmission related to dural grafting following various neurosurgical procedures. amyloid-ß proteins cadaveric cerebral amyloid angiopathy dural allotransplants Edinburgh criteria iatrogenic intracerebral hemorrhage lobar prion-like transmission recurrent simplified spontaneous true false true Angleški jezik Ni določen Neznano 2026-03-09 10:59:46 2026-03-09 10:59:47 2026-03-10 03:52:29 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 2. 6. 2025; str. 1-7 [article no.] 165 Vol. 16 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2152-7806 10.25259/SNI_245_2025 237915395 RAZ_Frol_Senta_2025.pdf RAZ_Frol_Senta_2025.pdf 1 C1EE5FAB927DEA72926F3F7303EEE160 b56ee5d982152616bf77d67214bbb0e6d075b3473d6d8fb1ac0452b9e3943713 d23dfdcb-1b9f-11f1-b779-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41425 https://doi.org/10.25259/sni_245_2025 0 faf5a3d3-1b9f-11f1-b779-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41426 Univerzitetni klinični center Ljubljana 0 0 0