20.500.12556/DiRROS-28030 Comparison of creatinine-, cystatin C-, and combined creatinine–cystatin C-based equations for estimating glomerular filtration rate a real-world analysis in patients with chronic kidney disease The estimated glomerular filtration rate (eGFR) is a cornerstone of kidney function assessment. Widely used Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations based on serum creatinine (eGFRcr), cystatin C (eGFRcysC), or both (eGFRcr-cysC) are influenced by non-glomerular filtration rate (GFR) factors, and their performance may vary across clinical contexts. We retrospectively analyzed 435 adult patients with simultaneous serum creatinine and cystatin C measurements. eGFR was calculated using CKD-EPI 2021 (creatinine), CKD-EPI 2012 (cystatin C), and CKD-EPI 2021 (combined) equations. Patients were classified into Kidney Disease: Improving Global Outcomes (KDIGO) GFR categories (G1–G5), and discrepancies between equations were identified. 44 patients (10.1%) showed discordant GFR categorization across all three equations and underwent detailed clinical assessment. 16 of the 44 discordant cases had clinically confirmed chronic kidney disease (CKD). The combined equation aligned with the clinical diagnosis in all CKD cases. eGFRcr overestimated kidney function in 10/16 patients, while eGFRcysC produced lower values in 8/16, consistent with early CKD but potentially influenced by inflammation or obesity. Reclassification occurred in 9/16 patients when switching from eGFRcr to eGFRcr-cysC, including four who shifted from G2 to G3a–G4. A significant difference was observed between eGFRcr and eGFRcr-cysC (p < 0.05). The combined CKD-EPI equation demonstrated the best clinical concordance, supporting its broader use when diagnostic accuracy is essential. chronic kidney disease glomerular filtration rate eGFR CKD-EPI creatinine cystatin C GFR classification diagnostic accuracy kronična ledvična bolezen hitrost glomerularne filtracije eGFR CKD-EPI kreatinin cistatin C klasifikacija GFR diagnostična natančnost true false true Angleški jezik Slovenski jezik Neznano 2026-03-06 12:50:09 2026-03-06 12:50:10 2026-03-07 03:51:45 0000-00-00 00:00:00 2026 0 0 Nasl. z nasl. zaslona; Opis vira z dne 12. 1. 2026; 12 str. iss. 1, [article no.] 364 Vol. 27 2026 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616-07:616.61-008.6 1422-0067 10.3390/ijms27010364 264239363 RAZ_Osredkar_Josko_2026.pdf RAZ_Osredkar_Josko_2026.pdf 1 18481FD6F103EA53A6C7D7E80148F742 68376358a80ee386b51e83932fdb4109506530eb31b714a2eaae3b615492028c 301e82e4-1954-11f1-81cd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41371 https://www.mdpi.com/1422-0067/27/1/364 1 a30f083d-1952-11f1-81cd-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41370 Univerzitetni klinični center Ljubljana 0 0 0