20.500.12556/DiRROS-27921 Optimised anaesthesia in abdominal cancer surgery does not prevent increase in biomarkers of neuroinflammation Neurocognitive decline during the perioperative period represents a risk of significant complications, including dementia and death. The aim of our study was to observe the change in biomarkers of neuroinflammation in optimized anesthesia without clinical signs of perioperative neurocognitive decline. Observational study included high-risk surgical patients who underwent large intestinal resections. Balanced anaesthesia was used to maximize cerebral protection. The release of NSE, protein S-100, matrix metalloproteinase-9 (MMP-9) and other biomarkers of cerebral injury were measured in serum samples using immunochemical methods during and after surgery. Profiles of proteins MMP-9 and S-100 showed perioperative increase, which was in accordance with intraoperative cerebral injury. Despite the increase, the S-100 and NSE plasma levels remained within normal range. The study highlights the perioperative expression of proteins MMP-9 and S-100, which might be useful as biomarkers of cerebral injury in the context of balanced anesthesia during major abdominal surgery. Perioperativni nevrokognitivni upad predstavlja za bolnike tveganje za resne zaplete, vključno z demenco in celo smrtjo. Namen naše študije je bil opazovati spremembe v koncentracijah biomarkerjev nevroinflammacije, ob uporabi optimizirane anestezije in brez kliničnih znakov perioperativnega neurokognitivnega upada. V našo observacijsko študijo smo vključili kirurške bolnike z visokim tveganjem za zaplete, ki so prestali obsežne resekcije debelega črevesa. Uporabili smo uravnoteženo anestezijo z namenom najboljše zaščite možganov. Med operacijo in po njej smo v serumskih vzorcih z uporabo imunokemičnih metodmerili koncentracijo NSE, proteina S-100, matriksne metaloproteinaze-9 (MMP-9) in drugih označevalcev poškodbe možganov. Koncentracijska profila proteina MMP-9 in S-100 sta bila skladna z možnostjo medoperativne poškodbe možganov. Kljub porastu so vrednosti S-100 in NSE v plazmi ostale znotraj normalnega ob-močja. Koncentracija NSE je celo upadla, verjetno zaradi intraoperativne infuzije. Naša študija je pokazala, da uporaba nevroprotektivne anestezije lahko zmanjša stopnjo vnetja. Študija poudarja izražanje proteinov MMP-9 in S-100 kot možnih označevalcev možganske poškodbe v kontekstu uravnotežene anestezije med večjimi trebušnimi operacijami. biomarkers abdominal cancer surgery anaesthesia biomarkerji nevro vnetje koncentracija anastezija true false true Angleški jezik Slovenski jezik Neznano 2026-02-27 11:59:47 2026-02-27 11:59:48 2026-02-28 04:20:57 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 20. 5. 2025; str. 45-51 no. 1 Vol. 72 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 1580-3155 10.17344/acsi.2024.8901 236495363 RAZ_Jenko_Matej_2025.pdf RAZ_Jenko_Matej_2025.pdf 1 9B7B7C1EC685AE0410996C310C1658B7 0c009bde8801cb9420881da7cf17ff1d3f10710da34de7872924de9135800e55 9813b5cd-13cb-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41115 https://doi.org/10.17344/acsi.2024.8901 0 6fcefd42-13cb-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41114 Univerzitetni klinični center Ljubljana 0 0 0