20.500.12556/DiRROS-27914 Non-coding rnas as potential biomarkers for colorectal polyps and cancer detection Colorectal cancer (CRC) remains one of the leading causes of cancer-related death worldwide. The precursor of CRC is a colorectal polyp, of which adenoma is the most common histological type. The initial step in CRC development is the gradual accumulation of a series of genetic and epigenetic alterations in the normal colonic epithelium. Genetic alterations play a major role in a subset of CRCs, but the pathophysiological contribution of epigenetic aberrations has recently attracted attention. Epigenetic marks occur early in cancer pathogenesis and are therefore important molecular hallmarks of cancer. This makes some epigenetic alterations clinically relevant for early detection not only of CRC but also of precancerous polyps. In this review we focus on three types of non-coding RNAs as epigenetic regulators: miRNA, lncRNA, and lncRNAs, highlighting their biomarker potential. colorectal polyp colorectal cancer CRC genetic susceptibility non-coding RNAs epigenetic regulators true false true Angleški jezik Ni določen Neznano 2026-02-27 11:32:24 2026-02-27 11:32:24 2026-02-28 04:20:55 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 15. 5. 2025; str. 1-11 iss. 14, [article no.] 4106. Vol. 26 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 1422-0067 10.3390/ijms26094106 236005123 RAZ_Plut_Samo_2025.pdf RAZ_Plut_Samo_2025.pdf 1 DAE47FDDA02790EA316AB06445665135 a2aad4b049cadad9758f084f48e105a445bfa7a0a29b91ff589638272095c4f0 b71e268f-13c7-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41102 https://www.mdpi.com/1422-0067/26/9/4106 1 9bba224a-13c7-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41101 Univerzitetni klinični center Ljubljana 0 0 0