20.500.12556/DiRROS-27908 Quantitative MRI Assessment of supraspinatus tendon remodeling following a single platelet-rich plasma injection using T2 mapping and relaxation time profiling Background: Quantitative magnetic resonance imaging (MRI) techniques such as T2 mapping may detect early tendon changes following biologic therapies. This study aimed to assess the structural remodeling of the supraspinatus tendon using mean T2 values and T2 distribution profiles after an ultrasound (US)-guided single platelet-rich plasma (PRP) injection. Methods: Twenty-six patients with symptomatic supraspinatus tendinopathy were divided into tendinosis (n = 9) and partial tear (n = 13) groups. T2 mapping and clinical evaluations (shoulder pain and disability index questionnaire (SPADI), Constant-Murley score) were conducted at baseline and 6 months post-PRP. Mean T2 values were measured in three tendon segments (lateral, middle, and medial), and T2 profiles were compared to asymptomatic controls. Results: Clinical outcomes showed significant improvement in both the tendinosis and partial tear groups at the 6-month follow-up. Although no significant changes were observed in the mean T2 relaxation times across tendon segments following PRP treatment, T2 distribution profiling revealed statistically significant alterations in both groups. In the tendinosis group, post-treatment T2 profiles approached those of the asymptomatic controls, suggesting structural remodeling consistent with tendon healing. Conclusions:T2 mapping is an effective tool for detecting tendon remodeling following PRP therapy. Structural improvements indicative of tissue healing were observed in cases of tendinosis, but not in partial tendon tears. These findings support the use of T2 mapping-particularly the T2 distribution profiling-as a quantitative biomarker for assessing treatment response to PRP. T2 mapping magnetic resonance imaging supraspinatus tendon mapiranje T2 slikanje z magnetno resonanco tetiva supraspinatusa true false true Angleški jezik Slovenski jezik Neznano 2026-02-27 10:29:40 2026-02-27 10:29:41 2026-02-28 04:20:54 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 12. 5. 2025; str. 1-16 no. 8, [article no.] 1049 Vol. 15 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-07 2075-4418 10.3390/diagnostics15081049 235544067 RAZ_Pintaric_Karlo_2025.pdf RAZ_Pintaric_Karlo_2025.pdf 1 64E435F9C96E610CD446EFC77D02FF9E 5444a5002f8a1db9d841121d46c9fe004ae3afb21b92f7041743d828c16cd340 f71bf5d2-13be-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41089 https://www.mdpi.com/2075-4418/15/8/1049 1 d8355f00-13be-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41088 Univerzitetni klinični center Ljubljana 0 0 0