20.500.12556/DiRROS-27906 Smoking and lower extremity artery disease Cigarette smoking is a major preventable risk factor for lower extremity arterial disease (LEAD) and is strongly associated with a higher risk of disease progression, worse post-procedural outcomes, and increased healthcare utilization. Smoking provokes the development of atherosclerotic through different mechanisms. Endothelial cell dysfunction, oxidative stress, inflammation, and arterial stiffness are among the key factors related to the development of atherogenesis due to smoking. Smoking cessation among patients with LEAD and the use of smoking cessation methods, including pharmacological treatment, are mandatory. Given that smoking cessation interventions remain underutilized. Therefore, in this narrative review we highlight the importance of incorporating smoking cessation treatments as part of the medical management of LEAD. Regulatory approaches to reduce tobacco use and support smoking cessation have the potential to reduce the burden of LEAD. smoking peripheral arterial disease atherosclerosis true false true Angleški jezik Ni določen Neznano 2026-02-27 10:16:10 2026-02-27 10:16:10 2026-03-16 13:29:14 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 8. 5. 2025; str. 383-390 issue 5 Vol. 44 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 1827-1839 10.23736/S0392-9590.25.05302-7 235177475 RAZ_Antignani_Pier_Luigi_2025.pdf RAZ_Antignani_Pier_Luigi_2025.pdf 1 25C98D3DEF663F32F6A08FF574B62333 3d5da0ae7b77bb98accad20e49de13b7d5a4922d2dd9dda513fa54096e053b83 23f07cb7-13bd-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41085 https://www.minervamedica.it/en/journals/international-angiology/article.php?cod=R34Y2025N05A0383 0 f68be04e-13bc-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41084 Univerzitetni klinični center Ljubljana 0 0 0