20.500.12556/DiRROS-27901 Biologics in pediatric idiopathic nephrotic syndrome and other kidney diseases general principles and special considerations Idiopathic nephrotic syndrome (INS) and other pediatric kidney diseases represent significant challenges due to their complex pathogenesis, often involving dysregulated immune responses and renal injury. Biologic therapies, defined as targeted treatments derived from living organisms, have gained traction in managing these conditions, offering a potential shift in therapeutic paradigms. This review examines the current and emerging role of biologics in treating pediatric kidney diseases, focusing on indications, contraindications, adverse effects, therapeutic positioning, and a comparison with alternative immunosuppressive treatments nephrotic syndrome dysregulated immune responses biologic therapies adverse effects true false true Angleški jezik Ni določen Neznano 2026-02-27 09:50:40 2026-02-27 09:50:40 2026-02-28 04:20:53 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis z dne 7. 5. 2025; str. 1-11 iss. 4 Vol. 5 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 2572-9241 10.3390/biologics5010004 235037187 RAZ_Kopac_Matjaz_2025.pdf RAZ_Kopac_Matjaz_2025.pdf 1 E0A63D52AFC43B81207FE471A90F2C41 8ed4e528039fe058b28f20de74b18edc82e7acdf78e5461ef73c362393eb0937 8267af82-13b9-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41075 https://www.mdpi.com/2673-8449/5/1/4 1 652e1267-13b9-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41074 Univerzitetni klinični center Ljubljana 0 0 0