20.500.12556/DiRROS-27899 The impact of hydration on metabolic outcomes from arginine-vasopressin signaling to clinical implications Arginine-vasopressin peptide (AVP) plays a critical role in water balance and osmoregulation. However, emerging evidence suggests that AVP’s actions may expand beyond its traditional role, significantly influencing metabolic regulation, including glucose homeostasis, insulin sensitivity, lipid metabolism and energy balance. Elevated AVP levels are seen in various metabolic conditions, such as insulin resistance, metabolic syndrome, type 2 diabetes (T2D) and obesity, further highlighting its potential role as a metabolic regulator. As AVP levels are regulated by hydration status, studies have proposed that chronic hypohydration and persistently elevated AVP levels may contribute to metabolic dysfunction, where increased hydration and therefore AVP suppression may lead to potential metabolic improvements. By analyzing data from animal studies, human observational research and interventional trials, this review evaluates the current evidence on the potential causal relationships and impact of AVP on metabolic regulation, as well as exploring the role of hydration in AVP-mediated metabolic outcomes. arginine-vasopressin (AVP) hydration glucose regulation arginin-vazopresin (AVP) hidracija regulacija glukoze true false true Angleški jezik Slovenski jezik Neznano 2026-02-27 09:44:50 2026-02-27 09:44:50 2026-02-28 04:20:52 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 7. 5. 2025; str. 1-17 no. 5, [article no.] 838 Vol. 61 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.4 1648-9144 10.3390/medicina61050838 234972163 RAZ_Koceva_Andrijana_2025.pdf RAZ_Koceva_Andrijana_2025.pdf 1 FF1379D22A6CFC152466625E25483829 f8dfb9a63065c7bc657dd46688a957e0c190078167cb2601b2a1284bf09db648 aed3e9f9-13b8-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41071 https://www.mdpi.com/1648-9144/61/5/838 1 94c88679-13b8-11f1-8c73-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41070 Univerzitetni klinični center Ljubljana 0 0 0