20.500.12556/DiRROS-27867 Sex dependence of postoperative pulmonary complications a post hoc unmatched and matched analysis of LAS VEGAS Study objective: Male sex has inconsistently been associated with the development of postoperative pulmonary complications (PPCs). These studies were different in size, design, population and preoperative risk. We reanalysed the database of ‘Local ASsessment of Ventilatory management during General Anaesthesia for Surgery study’ (LAS VEGAS) to evaluate differences between females and males with respect to PPCs. Design, setting and patients Post hoc unmatched and matched analysis of LAS VEGAS, an international observational study in patients undergoing intraoperative ventilation under general anaesthesia for surgery in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs in the first 5 postoperative days. Individual PPCs, hospital length of stay and mortality were secondary endpoints. Propensity score matching was used to create a similar cohort regarding type of surgery and epidemiological factors with a known association with development of PPCs. Main results: The unmatched cohort consisted of 9697 patients; 5342 (55.1%) females and 4355 (44.9%) males. The matched cohort consisted of 6154 patients; 3077 (50.0%) females and 3077 (50.0%) males. The incidence in PPCs was neither significant between females and males in the unmatched cohort (10.0 vs 10.7%; odds ratio (OR) 0.93 [0.81–1.06]; P = 0.255), nor in the matched cohort (10.5 vs 10.0%; OR 1.05 [0.89–1.25]; P = 0.556). New invasive ventilation occurred less often in females in the unmatched cohort. Hospital length of stay and mortality were similar between females and males in both cohorts. Conclusions: In this conveniently–sized worldwide cohort of patients receiving intraoperative ventilation under general anaesthesia for surgery, the PPC incidence was not significantly different between sexes. general anaesthesia intraoperative ventilation operating room outcomes true false true Angleški jezik Ni določen Neznano 2026-02-26 12:11:43 2026-02-26 12:11:43 2026-02-27 03:58:38 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 10. 3. 2025; str. 1-9 Vol. 99, ǂ[article no.] ǂ111565 Dec. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 617 1873-4529 10.1016/j.jclinane.2024.111565 228508163 RAZ_Vermeulen_Tom_D._2024.pdf RAZ_Vermeulen_Tom_D._2024.pdf 1 2B92B2466E4F0612847F7244079632B5 b35c48f68849ea99d99f6a2e86481a5cdab68017d9d732f06358062ee70905a3 304db36c-1304-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41004 https://www.sciencedirect.com/science/article/pii/S0952818024001946/pdfft?md5=12235754cc5b4b4f0ca9b417fe062239&pid=1-s2.0-S0952818024001946-main.pdf 1 efa6bdeb-1303-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=41003 Univerzitetni klinični center Ljubljana 0 0 0