20.500.12556/DiRROS-27839 Long-term IGF-1 maintenance in the upper-normal range has beneficial effect on low-grade inflammation marker in adults with growth hormone deficiency The distinctive effects of maintaining the upper- (0–2) versus lower-normal (−2–0) range of IGF-1 SDS in adult growth hormone deficiency (AGHD) remain understudied. We conducted a cross-sectional study on 31 patients with AGHD receiving growth hormone replacement therapy (GHRT) with daily GH for >5 years, with a 2-year mean IGF-1 SDS ranging between −2 and +2. Patients were categorized into the upper- or lower-normal range IGF-1 SDS groups according to their 2-year mean. Associations of clinical characteristics, anthropometric parameters, laboratory tests, and vascular markers of subclinical atherosclerosis with the 2-year IGF-1 SDS range and 5-year mean IGF-1 SDS were explored. Long-term maintenance of upper-normal IGF-1 SDSs was more common in men and in patients with a longer duration of GHRT. Patients with tumor-related AGHD had a lower 5-year mean IGF-1 SDS. Long-term maintenance of IGF-1 SDS in the upper-normal range was associated with lower high-sensitivity C-reactive protein (hs-CRP) levels (median (25–75% range): 0.8 (0.6–1.1) vs. 1.8 (0.8–4.6); p = 0.005). Moreover, a negative correlation was identified between a hs-CRP and the 5-year mean IGF-1 SDS. The association between the upper-normal IGF-1 SDS range and lower body fat percentage lost significance after adjusting for sex, due to the higher proportion of male patients in the upper-normal IGF-1 SDS group. In conclusion, long-term maintenance of upper-normal IGF-1 SDSs was associated with male sex and reduced low-grade inflammation. Randomized controlled studies are needed to evaluate the long-term and sex-specific effects of targeting the upper- vs. lower-normal IGF-1 range in AGHD. adult growth hormone deficiency growth hormone replacement therapy IGF-1 range pomanjkanje rastnega hormona pri odraslih nadomestno zdravljenje z rastnim hormonom razpon IGF-1 true false true Angleški jezik Slovenski jezik Neznano 2026-02-26 11:00:04 2026-02-26 11:00:04 2026-02-27 03:58:34 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 30. 9. 2024; str. 1-14 iss. 5, [article no.] 2010 Vol. 26 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.4 1422-0067 10.3390/ijms26052010 227344899 RAZ_Klinc_Ana_2025.pdf RAZ_Klinc_Ana_2025.pdf 1 B866A4E1E55CD54742F662241E45626D a03a1fb3bd649b14df458155593ae698b81e4634095f7aa71d1d4476000f89fe 2a256eb0-12fa-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40962 https://www.mdpi.com/1422-0067/26/5/2010 1 ed523d0f-12f9-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40960 Univerzitetni klinični center Ljubljana 0 0 0