20.500.12556/DiRROS-27830 Stroke frequency, associated factors, and clinical features in primary systemic vasculitis a multicentric observational study Objectives: The cerebral vessels may be affected in primary systemic vasculitis (PSV), but little is known about cerebrovascular events (CVEs) in this population. This study aimed to determine the frequency of CVEs at the time of diagnosis of PSV, to identify factors associated with CVEs in PSV, and to explore features and outcomes of stroke in patients with PSV. Methods: Data from adults newly diagnosed with PSV within the Diagnostic and Classification Criteria in VASculitis (DCVAS) study were analysed. Demographics, risk factors for vascular disease, and clinical features were compared between patients with PSV with and without CVE. Stroke subtypes and cumulative incidence of recurrent CVE during a prospective 6-month follow-up were also assessed. Results: The analysis included 4828 PSV patients, and a CVE was reported in 169 (3.50%, 95% CI 3.00-4.06): 102 (2.13% 95% CI 1.73-2.56) with stroke and 81 (1.68% 95% CI 1.33-2.08) with transient ischemic attack (TIA). The frequency of CVE was highest in Behçet's disease (9.5%, 95% CI 5.79-14.37), polyarteritis nodosa (6.2%, 95% CI 3.25-10.61), and Takayasu's arteritis (6.0%, 95% CI 4.30-8.19), and lowest in microscopic polyangiitis (2.2%, 95% CI 1.09-3.86), granulomatosis with polyangiitis (2.0%, 95% CI 1.20-3.01), cryoglobulinaemic vasculitis (1.9%, 95% CI 0.05-9.89), and IgA-vasculitis (Henoch-Schönlein) (0.4%, 95% CI 0.01-2.05). PSV patients had a 11.9% cumulative incidence of recurrent CVE during a 6-month follow-up period. Conclusion: CVEs affect a significant proportion of patients at time of PSV diagnosis, and the frequency varies widely among different vasculitis, being higher in Behçet's. Overall, CVE in PSV is not explained by traditional vascular risk factors and has a high risk of CVE recurrence. cerebrovascular event primary systemic vasculitis stroke transient ischaemic attack cerebrovaskularni dodgodek primarni sistemski vaskulitis možganska kap prehodni ishemični napad true false true Angleški jezik Slovenski jezik Neznano 2026-02-26 09:22:53 2026-02-26 09:22:53 2026-02-27 03:58:33 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 7. 2. 2025; str. 3309-3320 iss. 6 Vol. 271 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 1432-1459 10.1007/s00415-024-12251-1 225876995 RAZ_Geraldes_Ruth_2024.pdf RAZ_Geraldes_Ruth_2024.pdf 1 ABDBE5B03C1886E248E113726DEE6211 865615ed895acb3446a31894d43649d80d1389e6bd9acc5eee9aa7e56fd91470 8a06cd9b-12ec-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40942 https://link.springer.com/article/10.1007/s00415-024-12251-1 1 5ad5f57a-12ec-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40940 Univerzitetni klinični center Ljubljana 0 0 0