20.500.12556/DiRROS-27775 Idarucizumab reversal in subdural hemorrhage a single-center experience Prompt reversal of anticoagulation in the elderly population with subdural hematoma (SDH) is critical to reduce morbidity and facilitate timely surgical intervention. In patients receiving dabigatran, idarucizumab provides rapid anticoagulation reversal. We evaluated clinical and radiological outcomes of dabigatran-treated SDH patients receiving idarucizumab, including those undergoing surgical management. We conducted a single-center retrospective observational study of dabigatran-treated patients who received idarucizumab reversal for traumatic or spontaneous SDH between 2016 and 2024. Hematoma evolution was monitored using follow-up computed tomography. Clinical and neurological outcomes were recorded. Of eleven included patients (mean age 80.8 ± 6.7 years; 36% female), falls were the primary cause (64%). SDH was chronic in 64% and acute in 36%, with associated traumatic lesions in 33%. Surgical evacuation was performed in 82% of cases. Anticoagulation was resumed in 27% of patients within 3–4 weeks post-discharge. The median Glasgow Outcome Scale Extended (GOSE) score was 5, indicating moderate disability. In-hospital mortality was 9.1%. Idarucizumab enabled rapid and safe dabigatran reversal in this high-risk elderly cohort, supporting both surgical and conservative SDH management. Functional outcomes were moderate and mortality was low, underscoring its clinical utility. Targeted reversal strategies remain essential, and further research should refine long-term anticoagulation management. subdural hematoma idarucizumab dabigatran anticoagulation reversal case series true false true Angleški jezik Ni določen Neznano 2026-02-24 14:15:15 2026-02-24 14:15:15 2026-02-25 03:50:49 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 20. 10. 2025; str. 1-12 iss. 10, [article no.] 1617 Vol. 15 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2075-1729 10.3390/life15101617 253800451 RAZ_Mrvar_Brecko_Anita_2025.pdf RAZ_Mrvar_Brecko_Anita_2025.pdf 1 6B8BCE2F0F5EB9849F8BA17D8D68F004 72c64638ae20156ee51dabb386725c49113caf076f3932abdde5a5c9935ac675 0a68899b-1183-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40828 https://doi.org/10.3390/life15101617 0 199526b1-1183-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40829 Univerzitetni klinični center Ljubljana 0 0 0