20.500.12556/DiRROS-27773 Influence of LDL cholesterol and Lp(a) on monocytes and macrophages in atherosclerosis Atherosclerosis is an active interaction between lipoproteins and inflammatory cells. Monocytes and macrophages are the most important immune cells involved in the process of atherosclerosis. They interact with atherogenic lipoproteins, in particular low density lipoprotein (LDL) cholesterol and lipoprotein(a) (Lp(a)). The increased concentration of the LDL cholesterol and Lp(a) accelerates the polarization of monocytes and macrophages toward proinflammatory phenotype and the formation of the foam cells. These cells then release large quantities of inflammatory cytokines that stimulate the oxidation of atherogenic lipoproteins that are even more atherogenic and contribute to the formation of foam cells and the secretion of the pro-inflammatory cytokines, thus creating a vicious circle. Surface marker C-C chemokine receptor type 2, expressed on monocytes/macrophages, enables their adhesion and migration into the subendothelial layer. The rupture of the atherosclerotic plaque on one hand, and the ability of the oxidized LDL cholesterol and Lp(a) to trigger arterial thrombosis by different mechanisms on the other hand, result in acute cardiovascular event. Here, we summarize the role of the monocytes and macrophages in atherosclerosis and explore the influence of LDL cholesterol and Lp(a) on monocytes and macrophages during the entire process of atherosclerosis, from its initiation to progression. atherosclerosis monocytes macrophages lipoprotein(a) LDL cholesterol true false true Angleški jezik Ni določen Neznano 2026-02-24 14:00:29 2026-02-24 14:00:29 2026-02-25 03:50:48 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 16. 10. 2025; str. 1-14 issue 3, ǂ[article no.] ǂ030503 Vol. 35 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.1 1846-7482 10.11613/BM.2025.030503 253395971 RAZ_Ugovsek_Sabina_2025.pdf RAZ_Ugovsek_Sabina_2025.pdf 1 45B04784E7202DF2A08022821990B473 46ec8b1e3a80666930d551d9886fdd792db3529748ef92c3b469cf782d4749a4 f93e4416-1180-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40824 https://doi.org/10.11613/BM.2025.030503 0 0b674fb6-1181-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40825 Univerzitetni klinični center Ljubljana 0 0 0