20.500.12556/DiRROS-27760 No more venous ulcers—what more can we do? Venous leg ulcers (VLUs) are the most severe complication caused by the progression of chronic venous insufficiency. They account for approximately 70–90% of all chronic leg ulcers (CLUs). A total of 1% of the Western population will suffer at some time in their lives from a VLU. Furthermore, most CLUs are VLUs, defined as chronic leg wounds that show no tendency to heal after three months of appropriate treatment or are still not fully healed at 12 months. The essential feature of VLUs is their recurrence. VLUs also significantly impact quality of life and could cause social isolation and depression. They also have a significant avoidable economic burden. It is estimated that the treatment of venous ulceration accounts for around 3% of the total expenditure on healthcare. A VLU-free world is a highly desirable aim but could be challenging to achieve with the current knowledge of the pathophysiology and diagnostic and therapeutical protocols. To decrease the incidence of VLUs, the long-term goal must be to identify high-risk patients at an early stage of chronic venous disease and initiate appropriate preventive measures. This review discusses the epidemiology, socioeconomic burden, pathophysiology, diagnosis, modes of conservative and invasive treatment, and prevention of VLUs. venous ulcer recurrent venous ulcer compression therapy conservative treatment invasive treatment costs prevention burden of illness true false true Angleški jezik Ni določen Neznano 2026-02-24 12:22:35 2026-02-24 12:22:35 2026-02-25 03:50:47 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Opis vira z dne 1. 10. 2025; str. 1-30 iss. 19, [article no.] 6153 Vol. 12 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616 2077-0383 10.3390/jcm12196153 251259651 RAZ_Stanek_Agata_2023.pdf RAZ_Stanek_Agata_2023.pdf 1 BA2BAB090686137BE8D18ADB5B4E3D76 839c5b90a8fdd0b436993fe96c62874aa7f2354ae6ef6003d6bce56a4fe02818 55983329-1173-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40798 https://doi.org/10.3390/jcm12196153 0 61d25941-1173-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40799 Univerzitetni klinični center Ljubljana 0 0 0