20.500.12556/DiRROS-27726 Invasive aspergillosis in liver transplant recipients in the current era Invasive aspergillosis (IA) is a rare but fatal disease among liver transplant recipients (LiTRs). We performed a multicenter 1:2 case-control study comparing LiTRs diagnosed with proven/probable IA and controls with no invasive fungal infection. We included 62 IA cases and 124 matched controls. Disseminated infection occurred only in 8 cases (13%). Twelve-week all-cause mortality of IA was 37%. In multivariate analyses, systemic antibiotic usage (adjusted odds ratio [aOR], 4.74; P ¼.03) and history of pneumonia (aOR, 48.7; P ¼ .01) were identified as independent risk factors associated with the occurrence of IA. Moreover, reoperation (aOR, 5.99; P ¼.01), systemic antibiotic usage (aOR, 5.03; P ¼.04), and antimold prophylaxis (aOR, 11.9; P ¼.02) were identified as independent risk factors associated with the occurrence of early IA. Among IA cases, Aspergillus colonization (adjusted hazard ratio [aHR], 86.9; P <.001), intensive care unit stay (aHR, 3.67; P ¼.02), disseminated IA (aHR, 8.98; P <.001), and dialysis (aHR, 2.93; P ¼.001) were identified as independent risk factors associated with 12-week all-cause mortality, while recent receipt of tacrolimus (aHR, 0.11; P ¼ .001) was protective. Mortality among LiTRs with IA remains high in the current era. The identified risk factors and protective factors may be useful for establishing robust targeted antimold prophylactic and appropriate treatment strategies against IA. invasive aspergillosis liver transplantation targeted antifungal prophylaxis true false true Angleški jezik Ni določen Neznano 2026-02-23 13:23:08 2026-02-23 13:23:08 2026-02-24 04:01:59 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 1. 8. 2025; str. 2092-2107 iss. 11 Vol. 24 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.36 1600-6143 10.1016/j.ajt.2024.05.016 244640515 RAZ_Kimura_Muneyoshi_2024.pdf RAZ_Kimura_Muneyoshi_2024.pdf 1 7A3FF35F061A2F42BB9E04593704C8E3 c971d9d87cdbc7f1a14edbc331a64ed76733c673bf20af3d47c89ff83a0aa8ef bd716ae6-10b2-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40729 https://doi.org/10.1016/j.ajt.2024.05.016 0 05eb2a03-10b3-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40730 Univerzitetni klinični center Ljubljana 0 0 0