20.500.12556/DiRROS-27719 Advancements in uterine sarcoma management a review Uterine sarcomas are rare, accounting for 3–7% of uterine malignancies. This review aims to summarize advancements in diagnostics and treatment over the last decade, focusing on innovative imaging techniques, molecular diagnostics, and treatment modalities. Recent diagnostic advancements include enhanced imaging techniques such as MRI and AI-driven algorithms, improving accuracy in differentiating between benign and malignant uterine tumors. Biomarkers like lactate dehydrogenase (LDH) and microRNAs have shown potential in preoperative identification. Treatment strategies continue to evolve, with surgical resection being the cornerstone. The role of lymphadenectomy and adnexectomy varies by histopathological subtype, emphasizing personalized approaches. Adjuvant therapies remain controversial, tailored to patient risk factors and tumor characteristics. Fertility-sparing options are viable for selected patients, though not recommended for high-grade tumors. Significant progress in diagnostic techniques and personalized treatment approaches has improved the management of uterine sarcomas. Future guidelines from major oncology groups are expected to standardize care. Continued research is essential for refining treatment protocols and enhancing patient outcomes. uterine sarcomas molecular diagnostics artificial intelligence treatment approache true false true Angleški jezik Ni določen Neznano 2026-02-23 10:45:41 2026-02-23 10:45:42 2026-02-24 04:01:57 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Opis vira z dne 9. 4. 2025; str. 1-6 iss. 4, [article no.] 109646 Vol. 51 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 1532-2157 10.1016/j.ejso.2025.109646 232012035 RAZ_Lebar_Vojka_2025.pdf RAZ_Lebar_Vojka_2025.pdf 1 102C26614D75E86DECBE776C2DF6DBA9 eb0914c00adce4b10f195a99ce0bc42bc66d0740f9c663e96792ed4c3737840e b50bc520-109c-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40717 https://www.sciencedirect.com/science/article/pii/S0748798325000745?via%3Dihub 1 6c487aa3-109c-11f1-9cb0-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40716 Univerzitetni klinični center Ljubljana 0 0 0