20.500.12556/DiRROS-27666 The Exposure and Health Examination Survey mother-child(ren) cohort profile applying the exposome to the comprehension of child’s health and development joining singletons and twins data he Exposure and Health Examination Survey (EXHES) cohort aims to elucidate the impact of environmental exposures (the external exposome) and their biological markers (the internal exposome) on childhood health conditions, asthma and allergies, obesity, and cognitive development in particular. Utilizing singletons and twins helped differentiate environmental effects from genetic influences due to the shared genetic background in twins. The EXHES cohort includes 2356 mother-child pairs across 10 European countries, comprising 1945 singletons and 411 twins, with data collected during the crucial first 1000 days of life. Data were gathered through epidemiological questionnaires and biomarkers, including blood, urine, hair, and breast milk from mothers, and cord blood, placenta, and cord tissues from children. Findings confirm that twin pregnancies are linked with increased risks of pregnancy complications, preterm birth, cesarean delivery, low birthweight, maternal health problems during pregnancy and a lower risk of macrosomia. Moreover, mothers of twins were more likely to have asthma, while higher maternal education was associated with a lower likelihood of twin births. The EXHES cohort provides a robust framework to be adopted in other studies for comparing singletons and twins to better understand how the exposome affects early child development and health outcomes. This approach offers new insights into the interplay between environmental and biological factors in shaping long-term health. environmental exposure biomarkers okoljska izpostavljenost biomarkerji true false true Oxford University Press Združeno kraljestvo Angleški jezik Slovenski jezik © The Author(s) 2025. Neznano 2026-02-18 11:09:39 2026-02-18 11:09:40 2026-02-19 03:52:27 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Soavtorice iz Slovenije: Neža Palir, Darja Mazej, Janja Snoj Tratnik, Ingrid Falnoga, Milena Horvat; Opis vira z dne 6. 2. 2026; str. 1-13 iss. 1 Vol. 5 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2025-03-19 2025-09-01 2025-09-18 504.5 2635-2265 10.1093/exposome/osaf009 267622147 https://academic.oup.com/exposome/article/5/1/osaf009/8257602 1 f1a8a5db-0cb1-11f1-9c9d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40594 RAZ_Errahmani_Mohamed-Yassir_2025.pdf RAZ_Errahmani_Mohamed-Yassir_2025.pdf 1 7A2F0AE641A6DEC49744ACC1A34AE665 e10b82c6fd2dacf51c6c71faeb0dfeda64b9280aa8dec6d6248ba5ac15bb74c9 538cda63-0cb2-11f1-9c9d-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40595 Institut Jožef Stefan 0 0 0