20.500.12556/DiRROS-27590 RNA kot terapevtska tarča priložnosti in omejitve v sodobni medicini RNA as therapeutic target opportunities and limitations in modern medicine RNA je ključna biomolekula, ki poleg prenosa genetskih informacij uravnava celične procese in je pomembna terapevtska tarča. Njene regulatorne sposobnosti vključujejo utišanje genov ter usmerjanje epigenetskih modifikacij, kar omogoča razvoj zdravil, kot so protismiselni oligonukleotidi, male interferenčne RNA in aptameri. Protismiselni oligonukleotidi in male interfernčne RNA utišajo informacijsko RNA z vezavo na komplementarna zaporedja, medtem ko aptameri zavirajo interakcije med proteini. Kemijske modifikacije povečujejo stabilnost teh učinkovin. Določanje struktur RNA z metodami, kot so jedrska magnetna resonanca, krioelektronska mikroskopija in sekvenciranje, je ključno za razvoj terapij. Izzivi pri razvoju terapij RNA vključujejo dinamično naravo RNA, omejeno kemijsko raznolikost ter težave pri selektivnem ciljanju RNA is a vital biomolecule that regulates cellular processes and therefore serves as a key therapeutic target. Its regulatory abilities include gene silencing and guiding epigenetic modifications, enabling the development of drugs like antisense oligonucleotides, small interference RNAs, and aptamers. Antisense oligonucleotides and small interference RNAs silence mRNA by binding to complementary sequences, while aptamers inhibit protein-protein interactions. Chemical modifications enhance the stability of these agents. Determining RNA structures using techniques such as nuclear magnetic resonance, cryogenic electron microscopy and sequencing is crucial for therapy development. Challenges in developing RNA-based therapies include RNA’s dynamic nature, limited chemical diversity, and difficulties in selective targeting. aptameri male molekule RNA siRNA terapevtski oligonukleotidi aptamers RNA siRNA small molecules therapeutic oligonucleotides true false true Slovenski jezik Angleški jezik Neznano 2026-02-13 16:07:40 2026-02-13 16:07:41 2026-02-14 04:04:42 0000-00-00 00:00:00 2025 0 0 str. 184-192 št. 3 Letn. 76 julij 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-07-01 577.113:615 0014-8229 245882627 rna.pdf rna.pdf 1 54DC58E3EEC58E123F5E51454ADD2454 a7bb55270d3035ecbc5e8f5da3cda2bc5e1c07cf60e882a4d3a24f5376c9a000 becb23e1-08ed-11f1-bcbc-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40434 Slovensko farmacevtsko društvo Farmacevtski vestnik 0 0 0