20.500.12556/DiRROS-27586 Vodikov sulfid - signalna molekula s terapevtskim potencialom Hydrogen sulfide - a signaling molecule with therapeutic potential Vodikov sulfid je poleg ogljikovega monoksida in dušikovega oksida pomembna signalna molekula, ki se endogeno sintetizira s pomočjo specifičnih encimov. Sodeluje pri številnih fizioloških procesih, kot so vazodilatacija, nevromodulacija in zaščita nevronov. Pomembna je tudi njegova vloga pri zaščiti celic pred oksidativnim stresom, raziskave pa so pokazale, da sodeluje pri uravnavanju apoptoze in proliferacije celic. Poleg tega ima proti vnetne učinke, v določenih okoliščinah pa lahko deluje tudi provnetno. Kljub številnim koristnim učinkom je v visokih koncentracijah toksičen, saj zavira citokrom c oksidazo, kar zaustavi delovanje dihalne verige, vodi v nastanek reaktivnih kisikovih zvrsti in poškodbe celic. Donorje vodikovega sulfida bi lahko uporabili za zdravljenje določenih stanj, kot so ishemija miokarda, nevrodegenerativne bolezni in vnetna obolenja, vendar so nujne nadaljnje raziskave glede mehanizmov delovanja in varnosti teh spojin. Hydrogen sulfide, along with carbon monoxide and nitric oxide, is an important signaling molecule that is endogenously synthesized by specific enzymes. It is involved in various physiological processes, including vasodilation, neuromodulation, and neuroprotection. Its role in protecting cells from oxidative stress is significant, and research has shown that it also regulates apoptosis and cell proliferation. Additionally, hydrogen sulfide has anti-inflammatory properties, although in some contexts, it may exert pro-inflammatory effects. Despite its many beneficial actions, it is toxic at high concentrations, as it inhibits cytochrome c oxidase, disrupting the respiratory chain, promoting the formation of reactive oxygen species, and leads to cellular damage. hydrogen sulfide donors show potential for treating conditions such as myocardial ischemia, neurodegenerative diseases, and inflammatory disorders; however, their mechanisms of action and safety profiles require further investigation. citokrom c oksidaza nevrodegenerativne bolezni vazodilatacija vodikov sulfid cytochrome c oxidase hydrogen sulfide neurodegenerative diseases vasodilation true false true Slovenski jezik Angleški jezik Neznano 2026-02-13 15:54:04 2026-02-13 15:54:04 2026-02-16 08:54:50 0000-00-00 00:00:00 2025 0 0 Nasl. z nasl. zaslona; Besedilo v slov.; Opis vira z dne 26. 1. 2026; str. 320-326 št. 5 Letn. 76 dec. 2025 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2025-12-01 616.831-003.8 2536-4316 266065411 pavlin.pdf pavlin.pdf 1 38625A6AA595180BF46A83C8FD4021CD 0e9e70f0e8da8a660b0230c74ea10a67e6813eac0a84d397418ef1bbd501c244 d9e94479-08eb-11f1-bcbc-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=40430 Slovensko farmacevtsko društvo Farmacevtski vestnik 0 0 0